Research Paper Volume 16, Issue 7 pp 5905—5915

Cepharanthine maintains integrity of the blood-brain barrier (BBB) in stroke via the VEGF/VEGFR2/ZO-1 signaling pathway


Figure 9. VEGF-A abolished the protective effects of CEP on the expression of ZO-1 and endothelial permeability. Cells were exposed to OGD/R in the presence or absence of CEP (3 μM) or VEGF-A (10 ng/ml). (A) mRNA of ZO-1; (B) Endothelial permeability was measured using FITC-dextran; (C) The trans-endothelial electrical resistance (TEER) (**, P<0.01 vs. vehicle group; ##, P<0.01 vs. H/R group group; ^, P<0.05 vs. H/R+CEP group).