Research Paper Volume 16, Issue 6 pp 5751—5771

Comprehensive analysis of scRNA-seq and bulk RNA-seq reveal the characteristics of disulfidptosis and a prognostic signature in BLCA


Figure 2. Patterns of disulfidptosis and biological characteristics of each pattern. (A) Interactions between DRGs. (B) Cumulative distribution function curve. (C) Consensus matrix of the BLCA cohort with k = 2. (D) Kaplan-Meier curves show that the disulfidptosis pattern is significantly associated with OS in 904 patients in the meta-cohort. (E) Unsupervised clustering analysis was performed on 26 DRGs. (F) GSVA enrichment analysis showed the activation states of biological pathways in distinct disulfidptosis patterns. (G) Principal component analysis of the DRG clustering patterns. (H) The abundance of each TME infiltrating cell in two disulfidptosis patterns. *P < 0.05, **P < 0.01, ***P < 0.001.