Research Paper Volume 16, Issue 8 pp 6757—6772

USP15 facilitates the progression of bladder cancer by amplifying the activation of the NF-κB signaling pathway


Figure 1. USP15 expression is apparently upregulated in bladder cancer tissues. (A) Human USP15 expression levels in different tumor types from TCGA database were determined by TIMER (*p < 0.05, **p < 0.01, ***p < 0.001). (B) Differential USP15 mRNA expression between bladder cancer tissues and normal tissues was determined by qRT-PCR. (C) Determination and quantification of USP15 protein levels in BCA tissues and paired non-tumor tissues by Western blotting (n = 50, ***p < 0.001). (D) Analysis of the relationship between overall survival rate and gene expression, based on high (n = 201) or low (n = 201) USP15 expression in TCGA patients.