Research Paper Volume 16, Issue 8 pp 6773—6795

An LRPPRC-HAPSTR1-PSMD14 interaction regulates tumor progression in ovarian cancer


Figure 4. HAPSTR1 knockdown repressed the proliferation, migration, and invasion capacities of ovarian cancer cells. (A) Efficiency of HAPSTR1 knockdown was examined by real-time PCR and Western blotting assays. (B, C) The decline in cell viability induced by HAPSTR1 knockdown was detected by colony formation and CCK-8 assays. (DF) The results of the transwell and wound healing assays showed that HAPSTR1 knockdown inhibited migration and invasion. Original magnification, 200x. (G, H) Flow cytometry was carried out to detect cell apoptosis rates. Each experiment was repeated with three independent replicates. *, p < 0.05; **, p < 0.01; ***, p < 0.001.