Research Paper Volume 16, Issue 8 pp 6921—6936

Compound sophora decoction alleviates ulcerative colitis by regulating macrophage polarization through cGAS inhibition: network pharmacology and experimental validation


Figure 6. CSD-regulated macrophage polarization in vivo. (A) Flow cytometry diagram of M1 and M2 in the spleen, mesenteric lymph nodes, and intestine of mice; (B) M2/M1 ratio of spleen in mice; (C) M2/M1 ratio of mesenteric lymph nodes in mice; (D) M2/M1 ratio of intestine in mice; (E) Representative western blot of iNOS and Arg1 in intestine; (F) Statistical map of iNOS protein content in intestine; (G) iNOS mRNA levels in intestine; (H) Statistical map of Arg1 protein content in the intestine; (I) Arg1 mRNA levels in intestine. The results are mean ± SD, n = 3–6, *p < 0.05, **p < 0.01, ***p < 0.001 vs. DSS group.