Research Paper Volume 16, Issue 8 pp 6937—6953

High-dose Vitamin C injection ameliorates against sepsis-induced myocardial injury by anti-apoptosis, anti-inflammatory and pro-autophagy through regulating MAPK, NF-κB and PI3K/AKT/mTOR signaling pathways in rats


Figure 2. High-dose VC relieved the myocardial dysfunction in CLP-induced sepsis rats at 1d, 3d and 5d. (AC) Echocardiographic image of each group of rats. LVEF and LVFS were quantified via echocardiography. (D) Myocardial injury was detected by H&E staining. (EG) Myocardial injury markers in serum, cTnI, CK, and LDH were detected to visualize myocardial injury using a fully automated biochemical analyzer. Data are expressed as mean ± SD (at least n = 6/group), #p < 0.05 (vs. Sham group), *p < 0.05 (vs. CLP group).