Research Paper Volume 16, Issue 8 pp 6937—6953

High-dose Vitamin C injection ameliorates against sepsis-induced myocardial injury by anti-apoptosis, anti-inflammatory and pro-autophagy through regulating MAPK, NF-κB and PI3K/AKT/mTOR signaling pathways in rats


Figure 3. High-dose VC suppressed the cardiomyocyte apoptosis in CLP-induced sepsis rats at 1d, 3d and 5d. (A) Apoptotic cells were detected by TUNEL staining. (BF) Representative images of Caspase-3 activity, Cleaved-caspase 3, Cleaved-caspase 9, and Bax and Bcl-2 expression were examined by western blot and the fold activation data analysis. Data are expressed as mean ± SD (at least n = 6/group), #p < 0.05(vs. Sham group), *p < 0.05 (vs. CLP group).