Research Paper Volume 16, Issue 8 pp 6937—6953

High-dose Vitamin C injection ameliorates against sepsis-induced myocardial injury by anti-apoptosis, anti-inflammatory and pro-autophagy through regulating MAPK, NF-κB and PI3K/AKT/mTOR signaling pathways in rats


Figure 4. High-dose VC attenuated the inflammatory response in CLP-induced sepsis rats at 1d, 3d and 5d. (AD) The serum inflammatory cytokines (i.e., TNF-α, IL-1β, IL-6, and IL-10) in serum were measured by ELISA. (EJ) Representative images of phosphorylation levels of P38, Erk1/2, JNK, NF-κB and IKK α/β were examined by western blot and the fold activation data analysis. Data are expressed as mean ± SD (at least n = 6/group), #p < 0.05 (vs. Sham group), *p < 0.05 (vs. CLP group).