Research Paper Volume 16, Issue 8 pp 6937—6953

High-dose Vitamin C injection ameliorates against sepsis-induced myocardial injury by anti-apoptosis, anti-inflammatory and pro-autophagy through regulating MAPK, NF-κB and PI3K/AKT/mTOR signaling pathways in rats


Figure 6. High-dose VC inhibited the PI3K/AKT/mTOR signaling pathway in CLP-Induced sepsis rats. (AD) Representative images of the phosphorylation of PI3K, AKT and mTOR were examined by western blot and the fold activation data analysis. (E, F) The expression of the proteins p-Akt and p-PI3K was examined by immunofluorescence assay. Data are expressed as mean ± SD (at least n = 6/group), #p < 0.05 (vs. Sham group), *p < 0.05 (vs. CLP group).