Research Paper Volume 16, Issue 8 pp 6990—7008

Activating transcription factor 6 alleviates secondary brain injury by increasing cystathionine γ-lyase expression in a rat model of intracerebral hemorrhage


Figure 1. Experimental mechanism diagram and experiment design. (A) Experimental mechanism: after ICH, ATF6 in neurons can promote the transformation of microglia into M2 by regulating the expression of CTH, inhibit inflammation, inhibit cell death, protect the blood-brain barrier, and relieve oxidative stress. (B) Experiment 1: the time course changes of ATF6 after ICH. (C) Experiment 2: the role of ATF6 in ICH-induced brain injury.