Research Paper Volume 16, Issue 8 pp 7009—7021

Whole-transcriptome profiling reveals potential biomarkers for the reversal of thymic epithelial cell senescence by umbilical cord mesenchymal stem cells


Figure 4. ceRNAs reverse TEC senescence via UCMSCs. (A) GO enrichment analysis inside the ceRNA network for mRNAs. (B) KEGG enrichment analysis of mRNAs in ceRNA networks. (C) Distinct mRNA, miRNA, and lncRNA expression patterns within the ceRNA network. miRNAs are represented by the green inverted triangle nodes, lncRNAs by the light pink quadrilateral nodes, and mRNAs by the red hexagon nodes. (D) Objective results of VEGFA and novel-m0297-5p RNA sequencing were verified by RT-PCR. The measured values represent the mean ± standard deviation (X ± s) of three replicate experiments. *P < 0.05, **P < 0.01.