Research Paper Volume 16, Issue 7 pp 5811—5828

The impact of continuous and intermittent ketogenic diets on cognitive behavior, motor function, and blood lipids in TgF344-AD rats


Figure 1. Body weight in wild type (WT) and TgF344-AD (Tg) rats on control diet (CD), intermittent ketogenic diet (IKD) or ketogenic diet (KD). (AD) Mean body weights ± SEM of male (A, B) and female (C, D) rats fed CD, IKD, and KD fed rats throughout the 2 (8-month, A and C) and 6-month (12-month, B and D) diet intervention (n = 14–15/group). Both sexes and diet time courses showed significant time effect (p < 0.0001). Body weights at termination at 8 (E) or 12-months (F) of age demonstrated a significant sex (p < 0.0001) effect. p < 0.05 and ∗∗∗p < 0.001 indicate significant differences between genotypes or diets based on repeated measures two-way ANOVA followed with Tukey’s post-hoc pairwise comparisons.