Research Paper Volume 16, Issue 7 pp 5811—5828

The impact of continuous and intermittent ketogenic diets on cognitive behavior, motor function, and blood lipids in TgF344-AD rats


Figure 2. Elevation of circulating level of β-hydroxybutyrate (BHB) with IKD and KD in TgF344-AD rats. Mean circulating BHB levels (± SEM) were measured in male (AC, n = 7–10/group) and female (DF, n = 8/group) rats fed control diet (CD), intermittent ketogenic diet (IKD) or ketogenic diet (KD). Pre- and postprandial measurements were taken at 8 (A, D), 10 (B, E) and 12 (C, F) months of age (2, 4, or 6 months after initiation of diet). Data were analyzed by repeated measures two-way ANOVA followed with the Tukey’s post-hoc pairwise comparisons. *p < 0.05 and **p < 0.01 indicate significant differences between timepoints within a diet group. Different letters of a, b, or c denote difference (p < 0.05) between diets at the AM fast. $ denote difference (p < 0.05) between diets at Fed AM timepoint. Both sexes showed significant overall diet and time effect at 2, 4 and 6 months (p < 0.0001).