Research Paper Volume 16, Issue 7 pp 5811—5828

The impact of continuous and intermittent ketogenic diets on cognitive behavior, motor function, and blood lipids in TgF344-AD rats


Figure 4. Motor coordination and muscle strength in TgF344-AD rats fed IKD and KD diet. Rotarod maximum speed (A, B, n = 9–14/group), grip strength (C, D, n = 13–15/group), and total distance traveled in open field (E, F, n = 13–15/group) were assessed in wild type (WT) and Tg433-AD (Tg) rats. Rats were assessed at 8 (A, C, and E) or 12 (B, D, and F) months of age and data were analyzed by two-way ANOVA followed with the Tukey’s post-hoc pairwise comparisons. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Diets: control (CD), intermittent ketogenic (IKD) and ketogenic (KD). Both timepoints (8 and 12 month) showed a significant sex effect in rotarod, grip strength test, and open field (p < 0.05).