Research Paper Volume 16, Issue 7 pp 5811—5828

The impact of continuous and intermittent ketogenic diets on cognitive behavior, motor function, and blood lipids in TgF344-AD rats


Figure 6. Spatial memory in IKD and KD fed TgF344-AD rats. Barnes maze latency to the target hole (A, B), pathlength to target hole (C, D) and time spent in the target quadrant (E, F) in the probe trial of the Barnes maze test was determined in wild type (WT) and Tg433-AD (Tg) rats. Behaviors were assessed at 8 (A, C and E, n = 11–15/group) or 12 (B, D, and F, n = 13–15/group) months of age and data were analyzed by two-way ANOVA followed with the Tukey’s post-hoc pairwise comparisons. *p < 0.05, **p < 0.01. Diets: control (CD), intermittent ketogenic (IKD) and ketogenic (KD).