Research Paper Volume 16, Issue 8 pp 7119—7130

Single session of intermittent theta burst stimulation alters brain activity of patients in vegetative state


Figure 1. Protocol of the experiment. (A) Structure of the sham-controlled, cross-over study. Each patient received two randomized sessions of stimulation (a real and a sham session). The real and sham sessions had at least a three-day washout period in between. The Coma Recovery Scale-Revised (CRS-R) assessment and fifteen minutes of electroencephalography (EEG) recording were conducted at the beginning of each session. 70 minutes of EEG recording, followed by another CRS-R assessment, was recorded immediately after each stimulation. T1, T2 and T3 refer to the EEG recording at 0-10 min, 30-40 min and 60-70 min, respectively. (B) Intermittent theta burst stimulation (iTBS) setup used in the study. Each stimulation included 600 stimuli: 20 trains of 50Hz bursts (3 pulses) repeated at 5Hz.