Research Paper Volume 16, Issue 8 pp 7141—7152

Aberrant expression of thyroidal hormone receptor α exasperating mitochondrial dysfunction induced sarcopenia in aged mice


Figure 1. Changes in body weight (BW), gastrocnemius muscle weight (Ga weight), four-limb grip strength (Grip), MCSA, and expression of myogenesis and senescence-related makers during aging. (A) Body weight of mice; (B) Ga weight of mice; (C) Ga weight normalized by BW (Ga weight/BW); (D) Grip strength of mice; (E) Grip strength normalized by BW (Grip/BW), n=10 for 6m group, n=9 for 15m group, n=11 for 24m group (AE); (F) Representative H&E staining images of Ga muscle section and quantitative analysis of MCSA level of three groups, Scale bar: 50 μm, n=3; (G) mRNA levels of myogenesis and senescence-related makers, n=7; (H) Representative Western blots and (I) quantification of Myf5, MyoD1, MyoG and Gapdh (loading control), n=3. *p<0.05, **p<0.01, ***p<0.001 vs. 6m group; #p<0.05, ##p<0.01 vs. 15m group.