Research Paper Volume 16, Issue 8 pp 7141—7152

Aberrant expression of thyroidal hormone receptor α exasperating mitochondrial dysfunction induced sarcopenia in aged mice


Figure 2. Increased ROS production and altered mitochondrial regulators of SM in mice during aging. (A) Representative ROS fluorescence staining of Ga muscles and quantification, Scale bar: 100 μm, n=3; (B) mRNA levels of mitochondrial biogenesis, mitochondrial dynamics and mitophagy/autophagy-related markers, n=7; (C) Representative Western blots and (D) quantification of Mfn1, Drp1, Pink1, DJ-1, LC3II/I, p62 and Gapdh (loading control), n=3. *p<0.05, **p<0.01, ***p<0.001 vs. 6m group; #p<0.05, ##p<0.01 vs. 15m group.