Research Paper Volume 16, Issue 8 pp 7188—7216

Integrative analysis based on the cell cycle-related genes identifies TPX2 as a novel prognostic biomarker associated with tumor immunity in breast cancer


Figure 10. TPX2-related gene network, protein–protein interactions and enrichment analysis. (A) Top 5 TPX2-correlated genes in TCGA database, KIF4A, BUB1, PLK1, KIF20A and CKAP2L, Pearson’s correlation coefficients. (B) The heatmap revealing the correlation between TPX2 expression and these top 5 genes in various tumors. (C) PPI network construction of 48 experimentally verified TPX2-interacted proteins. (D) An intersection analysis of the TPX2-interacted and TPX2-correlated genes. (E) Enrichment analysis illustration based on the TPX2-interacted and TPX2-correlated genes. (BP: biological process; CC: cellular component; MF: molecular function; KEGG: Kyoto Encyclopedia of Genes and Genomes).