Research Paper Volume 16, Issue 9 pp 8019—8030

AURKB promotes colorectal cancer progression by triggering the phosphorylation of histone H3 at serine 10 to activate CCNE1 expression


Figure 5. AURKB activated CCNE1 to facilitate CRC tumor growth in vivo. Xenograft tumors were developed in mice using HCT116 cells treated with shNC, shAURKB, and shAURKB + oeCCNE1. (A) Representative images of tumors resected from the experimental mice. (B, C) Weight and volume of the resected xenograft tumors. (D) Western blot detected the expression of AURKB and CCNE1 in the xenograft tumors. *p < 0.05, **p < 0.01.