Research Paper Volume 16, Issue 9 pp 8044—8069

Bioinformatics analysis for constructing a cellular senescence-related age-related macular degeneration diagnostic model and identifying relevant disease subtypes to guide treatment

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Figure 12. Transcription factors-hub genes and miRNA-hub genes regulatory networks in subtype A. (A) TF-hub genes network. The orange circles indicate hub genes and the green circles indicate TFs. (B) Ranking TFs based on degree centrality. (C) miRNA-mRNA regulatory network. The orange ellipses indicate hub genes and the green rhombuses indicate miRNAs. (D) Ranking miRNAs based on degree centrality. The number of adjacent nodes.