Research Paper Volume 16, Issue 9 pp 7553—7577

Biological sex, sex steroids and sex chromosomes contribute to mouse cardiac aging


Figure 7. Gene expression of common LV genes up-regulated during cardiac aging in male (A) and female (B) mice. Myh7, Myosin heavy chain beta, Bdh1, 3-Hydroxybutyrate Dehydrogenase 1, Myot, Myotilin, Postn, Periostin, Cpxm2, Inactive Carboxypeptidase-Like Protein X2. (C) (males) and (D) (females). Downregulated genes and genes have different modulations with aging between Gx and non-Gx animals or between males and females. Slc38a1, Solute Carrier Family 38 Member 1, CD74, CD molecule, Fmo2, Flavin Containing Dimethylaniline Monooxygenase 2 and Zbtb16, Zinc Finger and BTB Domain Containing 16. Results are expressed as the mean ± SEM (n = 4). One-way ANOVA followed by Holm-Sidak post-test. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 between indicated groups.