Research Paper Advance Articles

Figure 1. Impact of aged fecal microbiome transplantation (FMT) on cardiac function in recipient mice. (A) Female specific pathogen-free (SPF) mice were administrated with antibiotics (ABX) and subsequently subjected to FMT from young and aged mice prior myocardial infarction (MI) (upper panel). The lower panel illustrates the bacterial load in the stools of female mice following FMT. (B) The post-MI survival curve for female mice subjected to FMT from young and aged mice. (C) Post-FMT abundance of top 11 bacteria genera in female mice. (D) Cardiac ejection fraction (EF, %) of female mice before and after FMT and MI. (E) Picrosirius red staining for post-MI cardiac fibrosis of female mice receiving FMT. (F) Statistical analysis of post-MI cardiac fibrosis of female mice receiving FMT. Two-way ANOVA with Tukey post-hoc test was used to analyze data in A, D and F. Data are represented as mean ± SEM.