Aging | Advance

LncRNA H19 diminishes dopaminergic neuron loss by mediating microRNA-301b-3p in Parkinson’s disease via the HPRT1-mediated Wnt/β-catenin signaling pathway

Jingjing Jiang, Xuanyu Piao, Siying Hu, Jingbo Gao, Min Bao,

https://doi.org/10.18632/aging.102877

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The TβR II-targeted aptamer S58 prevents fibrosis after glaucoma filtration surgery

Xueru Li, Yu Leng, Xiangji Li, Yawei Wang, Peng Luo, Chi Zhang, Ziwen Wang, Xiaofeng Yue, Chongxing Shen, Long Chen, Zujuan Liu, Chunmeng Shi, Lin Xie,

https://doi.org/10.18632/aging.102997

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GSG2 (Haspin) promotes development and progression of bladder cancer through targeting KIF15 (Kinase-12)

Yuhao Chen, Dian Fu, Hai Zhao, Wen Cheng, Feng Xu,

https://doi.org/10.18632/aging.103005

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lncRNA OGFRP1 functions as a ceRNA to promote the progression of prostate cancer by regulating SARM1 level via miR-124-3p

Keqiang Yan, Lifang Hou, Tiantian Liu, Wei Jiao, Qian Ma, Zhiqing Fang, Shimin Zhang, Daoqing Song, Jikai Liu, Xinghua Gao, Yidong Fan,

https://doi.org/10.18632/aging.103007

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Inhibition of circulating exosomal microRNA-15a-3p accelerates diabetic wound repair

Yuan Xiong, Lang Chen, Tao Yu, Chenchen Yan, Wu Zhou, Faqi Cao, Xiaomeng You, Yingqi Zhng, Yun Sun, Jing Liu, Hang Xue, Yiqiang Hu, Dong Chen, Bobin Mi, Guohui Liu,

https://doi.org/10.18632/aging.103143

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in vivo cellular evidence of autophagic associated spermiophagy within the principal cells during sperm storage in epididymis of the turtle

Imran Tarique, Yonghong Shi, Noor Samad Gandahi, Baitao Ding, Ping Yang, Chang Chen, Waseem Ali Vistro, Quisheng Chen,

https://doi.org/10.18632/aging.103144

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The role of SIRT1 in BMP2-induced chondrogenic differentiation and cartilage maintenance under oxidative stress

Yang Lu, Li Zhou, Lijun Wang, Shan He, Honglei Ren, Nian Zhou, Zhenming Hu,

https://doi.org/10.18632/aging.103161

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miR-125a-5p inhibits glycolysis by targeting hexokinase-II to improve pulmonary arterial hypertension

Li Luo, Lusheng Xiao, Guili Lian, Huajun Wang, Liangdi Xie,

https://doi.org/10.18632/aging.103163

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Sigma-1 receptor is involved in diminished ovarian reserve possibly by influencing endoplasmic reticulum stress-mediated granulosa cells apoptosis

Lile Jiang, Jinquan Cui, Cuilian Zhang, Juanke Xie, Shaodi Zhang, Dongjun Fu, Wei Duo,

https://doi.org/10.18632/aging.103166

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Overexpression of miR-142-5p inhibits the progression of nonalcoholic steatohepatitis by targeting TSLP and inhibiting JAK-STAT signaling pathway

Chao Zhou, Pu Wang, Lei Lei, Yi Huang, Yue Wu,

https://doi.org/10.18632/aging.103172

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A novel 3’,5’-diprenylated chalcone induces concurrent apoptosis and GSDME-dependent pyroptosis through activating PKCδ/JNK signal in prostate cancer

Yongqiang Zhang, Jue Yang, Zhonghang Wen, Xiaoyue Chen, Jia Yu, Dongbo Yuan, Bixue Xu, Heng Luo, Jianguo Zhu,

https://doi.org/10.18632/aging.103178

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Identification of potential novel differentially-expressed genes and their role in invasion and migration in renal cell carcinoma

Shen-Nan Shi, Xia Qin, Shuo Wang, Wen-Fu Wang, Yao-Feng Zhu, Yu Lin, Zun-Lin Zhou, Ben-Kang Shi, Xi-Gao Liu,

https://doi.org/10.18632/aging.103192

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Apelin enhances IL-1β expression in human synovial fibroblasts by inhibiting miR-144-3p through the PI3K and ERK pathways

Ting-Kuo Chang, Yu-Han Wang, Shu-Jui Kuo, Shih-Wei Wang, Chun-Hao Tsai, Yi-Chin Fong, Nan-Lin Wu, Shan-Chi Liu, Chih-Hsin Tang,

https://doi.org/10.18632/aging.103195

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BRD4 contributes to LPS-induced macrophage senescence and promotes progression of atherosclerosis-associated lipid uptake

Hui Wang, Haiping Fu, Ruigong Zhu, Xuan Wu, Xian Ji, Xuesong Li, Hong Jiang, Zhe Lin, Xin Tang, Shixiu Sun, Jiajing Chen, Xin Wang, Qingguo Li, Yong Ji, Hongshan Chen,

https://doi.org/10.18632/aging.103200

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Integrative analysis of genomic and epigenetic regulation of endometrial cancer

Qihang Zhong, Junpeng Fan, Honglei Chu, Mujia Pang, Junsheng Li, Yong Fan, Ping Liu, Congying Wu, Jie Qiao, Rong Li, Jing Hang,

https://doi.org/10.18632/aging.103202

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NAC1 attenuates BCL6 negative autoregulation and functions as a BCL6 coactivator of FOXQ1 transcription in cancer cells

Min Gao, Alice Laschuk Herlinger, Renchin Wu, Tian-Li Wang, Ie-Ming Shih, Beihua Kong, Leticia Batista Azevedo Rangel, Jin-Ming Yang,

https://doi.org/10.18632/aging.103203

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PIWI-interacting RNAs piR-13643 and piR-21238 are promising diagnostic biomarkers of papillary thyroid carcinoma

Zhengyan Chang, Guo Ji, Runzhi Huang, Hong Chen, Yaohui Gao, Weifeng Wang, Xuechen Sun, Jie Zhang, Jiayi Zheng, Qing Wei,

https://doi.org/10.18632/aging.103206

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Establishing immune scoring model based on combination of the number, function, and phenotype of lymphocytes

Guoxing Tang, Xu Yuan, Ying Luo, Qun Lin, Zhishui Chen, Xue Xing, Huijuan Song, Shiji Wu, Hongyan Hou, Jing Yu, Liyan Mao, Weiyong Liu, Feng Wang, Ziyong Sun,

https://doi.org/10.18632/aging.103208

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Body mass index across adult life and cognitive function in the American elderly

Yun Zhou, Tao Zhang, Daniel Lee, Lin Yang, Shengxu Li,

https://doi.org/10.18632/aging.103209

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Association of cerebrospinal fluid neurogranin levels with cognition and neurodegeneration in Alzheimer’s disease

Mei Xue, Fu-Rong Sun, Ya-Nan Ou, Xue-Ning Shen, Hong-Qi Li, Yu-Yuan Huang, Qiang Dong, Lan Tan, Jin-Tai Yu, Alzheimer’s Disease Neuroimaging Initiative,

https://doi.org/10.18632/aging.103211

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Prognostic value of microRNAs in pancreatic cancer: a meta-analysis

Fei Zhao, Chao Wei, Meng-Ying Cui, Qiang-Qiang Xia, Shuai-Bin Wang, Yue Zhang,

https://doi.org/10.18632/aging.103214

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Salidroside ameliorates Parkinson's disease by inhibiting NLRP3-dependent pyroptosis

Xue Zhang, Yiming Zhang, Rui Li, Lingpeng Zhu, Buqing Fu, Tianhua Yan,

https://doi.org/10.18632/aging.103215

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Development of a nomogram that predicts the risk for coronary atherosclerotic heart disease

Shuna Huang, Xiaoxu Xie, Yi Sun, Tingxing Zhang, Yingying Cai, Xingyan Xu, Huangyuan Li, Siying Wu,

https://doi.org/10.18632/aging.103216

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Resistance training increases muscle NAD⁺ and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals

Donald A. Lamb, Johnathon H. Moore, Paulo Henrique Caldeira Mesquita, Morgan A. Smith, Christopher G. Vann, Shelby C. Osburn, Carlton D. Fox, Hector L. Lopez, Tim N. Ziegenfuss, Kevin W. Huggins, Michael D. Goodlett, Andrew D. Fruge, Andreas N. Kavazis, Kaelin C. Young, Michael D. Roberts,

https://doi.org/10.18632/aging.103218

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Amphiregulin promotes cisplatin chemoresistance by upregulating ABCB1 expression in human chondrosarcoma

Yu-Wen Huang, Chih-Yang Lin, Hsiao-Chi Tsai, Yi-Chin Fong, Chien-Kuo Han, Yuan-Li Huang, Wen-Tung Wu, Shih-Ping Cheng, Hao-Chiun Chang, Kuang-Wen Liao, Shih-Wei Wang, Chih-Hsin Tang,

https://doi.org/10.18632/aging.103220

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PI3K-Akt-mTOR inhibition by GNE-477 inhibits renal cell carcinoma cell growth in vitro and in vivo

Xueting Ye, Jian-Wei Ruan, Hang Huang, Wei-Ping Huang, Yan Zhang, Fangyi Zhang,

https://doi.org/10.18632/aging.103221

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MiR-16-5p regulates postmenopausal osteoporosis by directly targeting VEGFA

Tao Yu, Xiaomeng You, Haichao Zhou, Wenbao He, Zihua Li, Bing Li, Jiang Xia, Hui Zhu, Youguang Zhao, Guangrong Yu, Yuan Xiong, Yunfeng Yang,

https://doi.org/10.18632/aging.103223

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Clioquinol improves motor and non-motor deficits in MPTP-induced monkey model of Parkinson’s disease through AKT/mTOR pathway

Liangqin Shi, Chao Huang, Qihui Luo, Yu Xia, Wentao Liu, Wen Zeng, Anchun Cheng, Riyi Shi, Chen Zhengli,

https://doi.org/10.18632/aging.103225

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Dexmedetomidine inhibits LPS-induced proinflammatory responses via suppressing HIF1α-dependent glycolysis in macrophages

Qingyuan Meng, Pinhao Guo, Zhengyu Jiang, Lulong Bo, Jinjun Bian,

https://doi.org/10.18632/aging.103226

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KMT2A regulates cervical cancer cell growth through targeting VDAC1

Changlin Zhang, Yijun Hua, Huijuan Qiu, Tianze Liu, Qian Long, Wei Liao, Jiehong Qiu, Nang Wang, Miao Chen, Dingbo Shi, Yue Yan, Chuanbo Xie, Wuguo Deng, Tian Li, Yizhuo Li,

https://doi.org/10.18632/aging.103229

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Pyrrolo [3,4-b]-quinolin-9-amine compound FZU-0038-056 suppresses triple-negative breast cancer partially through inhibiting the expression of Bcl-2

Danping Wang, Zhi Nie, Xiaoyan Jiang, Jinxiang Ye, Zhimin Wei, Dating Cheng, Chenyang Wang, Yingying Wu, Rong Liu, Haijun Chen, Ceshi Chen, Chunyan Wang,

https://doi.org/10.18632/aging.103232

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MicroRNA-214-3p targets the PLAGL2-MYH9 axis to suppress tumor proliferation and metastasis in human colorectal cancer

Zili Zhou, Liang Wu, Zhengyi Liu, Xudan Zhang, Shengbo Han, Ning Zhao, Haijun Bao, Wenzheng Yuan, Jinhuang Chen, Jintong Ji, Xiaogang Shu,

https://doi.org/10.18632/aging.103233

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Ovulation and ovarian wound healing are impaired with advanced reproductive age

Jamie N. Mara, Luhan T. Zhou, Megan Larmore, Brian Johnson, Rebecca Ayiku, Farners Amargant, Michele T. Pritchard, Francesca E. Duncan,

https://doi.org/10.18632/aging.103237

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Qigesan inhibits esophageal cancer cell invasion and migration by inhibiting Gas6/Axl-induced epithelial-mesenchymal transition

Lingyu Kong, Xin Lu, Xuanyu Chen, Yunyan Wu, Yushuang Zhang, Huijuan Shi, Jing Li,

https://doi.org/10.18632/aging.103238

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NF2 deficiency accelerates neointima hyperplasia following vascular injury via promoting YAP-TEAD1 interaction in vascular smooth muscle cells

Xiongshan Sun, Shuang Li, Xueqing Gan, Ken Chen, Dachun Yang, Yongjian Yang,

https://doi.org/10.18632/aging.103240

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Loss of macroH2A1 decreases mitochondrial metabolism and reduces the aggressiveness of uveal melanoma cells

Sebastiano Giallongo, Michelino Di Rosa, Rosario Caltabiano, Lucia Longhitano, Michele Reibaldi, Alfio Distefano, Oriana Lo Re, Angela Maria Amorini, Lidia Puzzo, Lucia Salvatorelli, Stefano Palmucci, Daniele Tibullo, Andrea Russo, Antonio Longo, Giacomo Lazzarino, Giovanni Li Volti, Manlio Vinciguerra,

https://doi.org/10.18632/aging.103241

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Physiological and metabolic features of mice with CRISPR/Cas9-mediated loss-of-function in growth hormone-releasing hormone

Mert Icyuz, Michael Fitch, Fang Zhang, Anil Challa, Liou Y. Sun,

https://doi.org/10.18632/aging.103242

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Identification and validation of hub microRNAs dysregulated in esophageal squamous cell carcinoma

Chen Sang, Ce Chao, Min Wang, Youpu Zhang, Guanghua Luo, Xiaoying Zhang,

https://doi.org/10.18632/aging.103245

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Association between metabolic syndrome and endometrial cancer risk: a systematic review and meta-analysis of observational studies

Lan Wang, Zhen-Hua Du, Jia-Ming Qiao, Song Gao,

https://doi.org/10.18632/aging.103247

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Development of a machine learning-based multimode diagnosis system for lung cancer

Shuyin Duan, Huimin Cao, Hong Liu, Lijun Miao, Jing Wang, Xiaolei Zhou, Wei Wang, Pingzhao Hu, Lingbo Qu, Yongjun Wu,

https://doi.org/10.18632/aging.103249

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Red blood cell distribution width is associated with neuronal damage in acute ischemic stroke

Rong-Hua Hong, Jian Zhu, Ze-Zhi Li, Jian Yuan, Pei Zhao, Jie Ding, Qing-Lei Fan, Jin Yang, Bao-Guo Liu, Jian Cai, De-Sheng Zhu, Yang-tai Guan,

https://doi.org/10.18632/aging.103250

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Construction of immune-related and prognostic lncRNA clusters and identification of their immune and genomic alterations characteristics in lung adenocarcinoma samples

Jia Li, Chenyue Zhang, Chenxing Zhang, Haiyong Wang,

https://doi.org/10.18632/aging.103251

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Gorlin syndrome-induced pluripotent stem cells form medulloblastoma with loss of heterozygosity in PTCH1

Yu Ikemoto, Toshiyuki Miyashita, Michiyo Nasu, Hiromi Hatsuse, Kazuhiro Kajiwara, Katsunori Fujii, Toshino Motojima, Ibuki Kokido, Masashi Toyoda, Akihiro Umezawa,

https://doi.org/10.18632/aging.103258

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Altered expression of fibroblast activation protein-α (FAP) in colorectal adenoma-carcinoma sequence and in lymph node and liver metastases

Jon Danel Solano-Iturri, Maider Beitia, Peio Errarte, Julio Calvete-Candenas, María C. Etxezarraga, Alberto Loizate, Enrique Echevarria, Iker Badiola, Gorka Larrinaga,

https://doi.org/10.18632/aging.103261

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Testosterone enhances mitochondrial complex V function in the substantia nigra of aged male rats

Tianyun Zhang, Yu Wang, Yunxiao Kang, Li Wang, Hui Zhao, Xiaoming Ji, Yuanxiang Huang, Wensheng Yan, Rui Cui, Guoliang Zhang, Geming Shi,

https://doi.org/10.18632/aging.103265

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Ellagic acid protects mice against sleep deprivation-induced memory impairment and anxiety by inhibiting TLR4 and activating Nrf2

Wenjun Wang, Liudi Yang, Tianlong Liu, Jingwen Wang, Aidong Wen, Yi Ding,

https://doi.org/10.18632/aging.103270

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Age-related cognitive decline in baboons: modeling the prodromal phase of Alzheimer's disease and related dementias

Stephanny Lizarraga, Etienne W. Daadi, Gourav Roy-Choudhury, Marcel M. Daadi,

https://doi.org/10.18632/aging.103272

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Overexpression of hsa_circ_0136666 predicts poor prognosis and initiates osteosarcoma tumorigenesis through miR-593-3p/ZEB2 pathway

Chao Zhang, Haibo Zhou, Kaizhen Yuan, Raoying Xie, Chun Chen,

https://doi.org/10.18632/aging.103273

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Both objective and paradoxical insomnia elicit a stress response involving mitokine production

Morena Martucci, Maria Conte, Rita Ostan, Antonio Chiariello, Filomena Miele, Claudio Franceschi, Stefano Salvioli, Aurelia Santoro, Federica Provini,

https://doi.org/10.18632/aging.103274

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LncRNA SOCS2-AS1 inhibits progression and metastasis of colorectal cancer through stabilizing SOCS2 and sponging miR-1264

Zhihai Zheng, Xiaoxiao Li, Heyi You, Xiaofeng Zheng, Xiaojiao Ruan,

https://doi.org/10.18632/aging.103276

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Human amnion-derived mesenchymal stem cells promote osteogenic differentiation of human bone marrow mesenchymal stem cells via H19/miR-675/APC axis

Xiaojie Ma, Yifeng Bian, Hua Yuan, Ning Chen, Yongchu Pan, Weina Zhou, Shiyu Gao, Xin Du, Shushu Hao, Zixin Yan, Xuan Li, Keyue Liu, Fan Xu, Yuli Wang, Yifei Du,

https://doi.org/10.18632/aging.103277

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Association between renal function impairment and multivessel involvement in patients with acute ST-elevation myocardial infarction

Rei-Yeuh Chang, Han-Lin Tsai, Malcolm Koo, How-Ran Guo,

https://doi.org/10.18632/aging.103299

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Chronic polypharmacy impairs explorative behavior and reduces synaptic functions in young adult mice

Francesca Eroli, Kristina Johnell, María Latorre Leal, Chiara Adamo, Sarah Hilmer, Jonas W. Wastesson, Angel Cedazo-Minguez, Silvia Maioli,

https://doi.org/10.18632/aging.103315

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First-in-class candidate therapeutics that target mitochondria and effectively prevent cancer cell metastasis: mitoriboscins and TPP compounds

Béla Ózsvári, Federica Sotgia, Michael P. Lisanti,

https://doi.org/10.18632/aging.103336

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Jingjing Jiang, Xuanyu Piao, Siying Hu, Jingbo Gao, Min Bao,

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Xueru Li, Yu Leng, Xiangji Li, Yawei Wang, Peng Luo, Chi Zhang, Ziwen Wang, Xiaofeng Yue, Chongxing Shen, Long Chen, Zujuan Liu, Chunmeng Shi, Lin Xie,

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Yuhao Chen, Dian Fu, Hai Zhao, Wen Cheng, Feng Xu,

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Keqiang Yan, Lifang Hou, Tiantian Liu, Wei Jiao, Qian Ma, Zhiqing Fang, Shimin Zhang, Daoqing Song, Jikai Liu, Xinghua Gao, Yidong Fan,

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Yuan Xiong, Lang Chen, Tao Yu, Chenchen Yan, Wu Zhou, Faqi Cao, Xiaomeng You, Yingqi Zhng, Yun Sun, Jing Liu, Hang Xue, Yiqiang Hu, Dong Chen, Bobin Mi, Guohui Liu,

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Imran Tarique, Yonghong Shi, Noor Samad Gandahi, Baitao Ding, Ping Yang, Chang Chen, Waseem Ali Vistro, Quisheng Chen,

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Yang Lu, Li Zhou, Lijun Wang, Shan He, Honglei Ren, Nian Zhou, Zhenming Hu,

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Li Luo, Lusheng Xiao, Guili Lian, Huajun Wang, Liangdi Xie,

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Lile Jiang, Jinquan Cui, Cuilian Zhang, Juanke Xie, Shaodi Zhang, Dongjun Fu, Wei Duo,

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Chao Zhou, Pu Wang, Lei Lei, Yi Huang, Yue Wu,

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Yongqiang Zhang, Jue Yang, Zhonghang Wen, Xiaoyue Chen, Jia Yu, Dongbo Yuan, Bixue Xu, Heng Luo, Jianguo Zhu,

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Shen-Nan Shi, Xia Qin, Shuo Wang, Wen-Fu Wang, Yao-Feng Zhu, Yu Lin, Zun-Lin Zhou, Ben-Kang Shi, Xi-Gao Liu,

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Ting-Kuo Chang, Yu-Han Wang, Shu-Jui Kuo, Shih-Wei Wang, Chun-Hao Tsai, Yi-Chin Fong, Nan-Lin Wu, Shan-Chi Liu, Chih-Hsin Tang,

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Hui Wang, Haiping Fu, Ruigong Zhu, Xuan Wu, Xian Ji, Xuesong Li, Hong Jiang, Zhe Lin, Xin Tang, Shixiu Sun, Jiajing Chen, Xin Wang, Qingguo Li, Yong Ji, Hongshan Chen,

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Qihang Zhong, Junpeng Fan, Honglei Chu, Mujia Pang, Junsheng Li, Yong Fan, Ping Liu, Congying Wu, Jie Qiao, Rong Li, Jing Hang,

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Min Gao, Alice Laschuk Herlinger, Renchin Wu, Tian-Li Wang, Ie-Ming Shih, Beihua Kong, Leticia Batista Azevedo Rangel, Jin-Ming Yang,

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Zhengyan Chang, Guo Ji, Runzhi Huang, Hong Chen, Yaohui Gao, Weifeng Wang, Xuechen Sun, Jie Zhang, Jiayi Zheng, Qing Wei,

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Guoxing Tang, Xu Yuan, Ying Luo, Qun Lin, Zhishui Chen, Xue Xing, Huijuan Song, Shiji Wu, Hongyan Hou, Jing Yu, Liyan Mao, Weiyong Liu, Feng Wang, Ziyong Sun,

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Yun Zhou, Tao Zhang, Daniel Lee, Lin Yang, Shengxu Li,

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