Research Paper Advance Articles
Assessment of lipid parameters and its association with risk of stage 1 hypertension: a cohort study in middle-aged and elderly Chinese
- 1 Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, People's Republic of China
- 2 Baiyun Branch of Nanfang Hospital, Southern Medical University, Guangzhou 510599, People's Republic of China
Received: May 8, 2024 Accepted: June 17, 2025 Published: July 14, 2025
https://doi.org/10.18632/aging.206280How to Cite
Copyright: © 2025 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Background: There is a correlation between dyslipidemia and elevated blood pressure, but the relationship between different lipid parameters and elevated blood pressure is inconsistent. Therefore, understanding the impact of dyslipidemia on blood pressure is significant for the prevention and control of ASCVD. Our study is aimed at assessing longitudinally the correlation between lipid parameters and the incidence of stage 1 hypertension in a large Chinese community population.
Methods: This community-based cohort study conducted from 2011 to 2014–2016 included 2,843 eligible individuals aged 40 years or older. The diagnosis of stage 1 hypertension was systolic blood pressure (SBP) 130~139 mmHg and/or diastolic blood pressure (DBP) 80~89 mmHg. We collect data through standardized questionnaires and clinical and biochemical measurements conducted in unified institutions. The relationship between lipid parameters and risk of stage 1 hypertension were estimated using multiple Cox regression analysis.
Results: During the follow-up period, 388 subjects (13.7%) developed stage 1 hypertension. Incidence of stage 1 hypertension gradually increased with the quartiles of triglycerides (TG) and the ratio of TG to high-density lipoprotein cholesterol (TG/HDL-C, all P < 0.0001). Multiple Cox regression analyses indicated that, compared to the quartile 1 of TG/HDL-C, quartile 4 was associated with higher risk of incident stage 1 hypertension (model 1: HR = 2.06, 95% CI 1.49–2.84; model 2: HR = 1.95, 95% CI 1.41–2.70; model 3: HR = 1.48, 95% CI 1.05–2.09).
Conclusions: Our study findings suggest that TG/HDL-C is independently associated with the incidence of stage 1 hypertension in the Chinese middle-aged and elderly population.
Abbreviations
γ-GGT: γ-glutamyl transferase; FPG: fasting plasma glucose; LDL-C: low density lipoprotein cholesterol; SBP: systolic blood pressure; DBP: diastolic blood pressure; MAP: mean artery pressure; WC: waist circumference; BMI: body mass index; TC: total cholesterol; TG: triglyceride; HDL-C: high density lipoprotein cholesterol; non-HDL-C: non-high-density lipoprotein cholesterol; IPAQ: International Physical Activity Questionnaire; MET-h/week: metabolic equivalent hours per week; ACC: American College of Cardiology; AHA: American Heart Association; ESH: European Society of Hypertension; ISH: International Society of Hypertension; NICE: National Institute for Health and Care Excellence; HbA1c: hemoglobin A1c; ASCVD: Atherosclerotic Cardiovascular Disease; CVD: cardiovascular disease; CKD: chronic kidney disease; NO: nitric oxide; SD: standard deviations; CI: confidence intervals; HR: hazard ratio.