Research Paper Advance Articles
Exosomes released from senescent cells and circulatory exosomes isolated from human plasma reveal aging-associated proteomic and lipid signatures
Figure 7. Summary of exosome-mediated intercellular communication in senescence and aging. A summary of our overall exosome proteomic findings from senescent human primary lung fibroblast cells that suggest potential mechanisms by which senescence is exacerbated and propagated to cause secondary senescence. Changes in inflammatory, antioxidants, and matrix remodeling-related proteins in exosomes (eSASP) from senescent cells may contribute to creating a senescent microenvironment that may influence and affect neighboring cells. Heatmaps show the top selected senescent fibroblast exosome proteins involved in inflammation, antioxidant, and ECM-remodeling pathways.