Research Paper Advance Articles

Figure 4. Trf1^Δ/Δ deleted mice show enhanced fitness compared to wild type mice. (A) Volume of dioxide produced (VCO2) (ml/min/Kg^k), energy expenditure rate (EE) (Kcal/day/Kg^k), food intake per day, respiratory quotient (RQ), rearing and activity monitorization during light and dark cycles in metabolic cages in 43 weeks females’ mice. Note that females without Trf1 produce more volume of CO2, tend to consume more energy, and have higher food intake than wild-types. (B) Volume of oxygen consumed (VO2), volume of carbon dioxide produced (VCO2) (ml/min/Kg^k), respiratory quotient (RQ), energy expenditure rate (EE) (Kcal/day/Kg^k), activity and rearing monitorization during light and dark cycles in 80 weeks females and male’s mice. Note that Trf1^Δ/Δ mice had significantly lower VO2, VCO2, and energy expenditure compared to wild-types. Error bars, s.e.m.; only significant values are shown; *P < 0.05; **P < 0.01; ***P < 0.001 determined by two-tailed Student’s t-test (A, B)