Volume 17, Issue 9

30 September, 2025
pp 2241—2451

About the Cover

The cover features Figure 4 "Acute effects of OT+A5i on de novo systemic proteomes of males and females" from Conboy et al.

Research Perspective

Analysis of the current state of frailty indexes and their implementation for aging intervention studies

Oliver G. Frost, Anna Barkovskaya, Michael J. Rae, Marcela Atzori, Abdelhadi Rebbaa, Amit Sharma,

https://doi.org/10.18632/aging.206307 pp 2241—2251

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Research Papers

Sex-specific longitudinal reversal of aging in old frail mice

Cameron Kato, Jessica Zheng, Cindy Quang, Sophia Siopack, Joana Cruz, Zachery R. Robinson, Nicole Fong, Zhixin A. Zhang, Patrick Young, Michael J. Conboy, Irina M. Conboy,

https://doi.org/10.18632/aging.206304 pp 2252—2277

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Deregulated miR-145 and miR-27b in Hutchinson-Gilford progeria syndrome: implications for adipogenesis

Felix Quirin Fenzl, Eva-Maria Lederer, Louisa Brumma, Peter Krüger, Moritz Schroll, Frederic Wilming, Karima Djabali,

https://doi.org/10.18632/aging.206309 pp 2278—2311

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The impact of long-term social housing on biconditional association task performance and neuron ensembles in the anterior cingulate cortex and the hippocampal CA3 region of aged rats

Anne M. Dankert, Abbi R. Hernandez, Taylor B. Wise, Katrina I. T. Dayaw, Judith N. T. Dayaw, Rachael M. Layden, Katelyn N. Lubke, Sara N. Burke, Victoria L. Templer,

https://doi.org/10.18632/aging.206310 pp 2312—2334

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Glycocalyx-targeted therapy prevents age-related muscle loss and declines in maximal exercise capacity

Daniel R. Machin, Md. Torikul Islam, Alec Malouf, Daniel Nguyen, Mostafa Sabouri, Maryana Boulos, Andrew G. Horn, Kiana M. Schulze, Gwenael Layec, Lisa A. Lesniewski, Anthony J. Donato,

https://doi.org/10.18632/aging.206313 pp 2335—2350

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Lactobacillus amylovorus KU4 inhibits adipocyte senescence in aged mice through necdin regulation of p53 activity

Garam Yang, Eunjeong Hong, Hyuno Kang, Sejong Oh, Eungseok Kim,

https://doi.org/10.18632/aging.206314 pp 2351—2368

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Runx1 overexpression induces early onset of intervertebral disc degeneration

Takanori Fukunaga, Martha Elena Diaz-Hernandez, John G. Heller, Changli Zhang, Hicham Drissi,

https://doi.org/10.18632/aging.206316 pp 2369—2391

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Roles of plasminogen activator inhibitor-1 in aging-related muscle and bone loss in mice

Takashi Ohira, Naoyuki Kawao, Yuya Mizukami, Kiyotaka Okada, Akihito Nishikawa, Hisatoshi Yamao, Ayaka Yamada, Hiroshi Kaji,

https://doi.org/10.18632/aging.206318 pp 2392—2409

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Depletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles

Jessica Louzame Ruano, Leire Bejarano, Rosa Serrano, Ruth Alvarez Diaz, Juana Maria Flores, Ana Cayuela López, Maria A. Blasco,

https://doi.org/10.18632/aging.206320 pp 2410—2429

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Review

Mitochondrial proteins as biomarkers of cellular senescence and age-associated diseases

Anna Panfilova, Tatiana Zubareva, Ekaterina Mironova, Gianluigi Mazzoccoli, Maria Greta Pia Marasco, Sofya Balazovskaia, Peter Yablonsky, Igor Kvetnoy,

https://doi.org/10.18632/aging.206305 pp 2430—2448

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Correction

Correction for: The regulation of p53 by phosphorylation: a model for how distinct signals Integrate into the p53 pathway

Nicola J. Maclaine, Ted R. Hupp,

https://doi.org/10.18632/aging.206321 pp 2449

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Retraction

Retraction of: Long non-coding RNA NNT-AS1 promotes cholangiocarcinoma cells proliferation and epithelial-to-mesenchymal transition through down-regulating miR-203

Yulei Gu, Zhiqiang Zhu, Hui Pei, Dong Xu, Yumin Jiang, Luanluan Zhang, Lili Xiao,

https://doi.org/10.18632/aging.206322 pp 2450—2451

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