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• Research Paper Volume 10, Issue 12 pp 4241-4247

  Circulating insulin-like growth factor-1: a new clue in the pathogenesis of age-related macular degeneration

  Relevance score: 8.544648

  Niccolò Castellino, Antonio Longo, Teresio Avitabile, Andrea Russo, Matteo Fallico, Vincenza Bonfiglio, Mario Damiano Toro, Robert Rejdak, Katarzyna Nowomiejska, Paolo Murabito, Claudio Furino, Michele Reibaldi

  Keywords: age‐related macular degeneration, neovascular AMD, IGF-1, anti‐VEGF, senescence, somatomedin C

  Published in Aging on December 29, 2018

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  In order to investigate Insulin-like growth factor-1 (IGF-1) blood levels in male and female age-matched patients affected by early, intermediate, neovascular age related macular degeneration (AMD) and healthy subjects (no AMD) were enrolled in a prospective, observational study. All patients enrolled were classified according to 4 stages classification of AMD from Age-related eye disease study (AREDS). Each subject underwent a complete ophthalmic examination including best corrected visual acuity (BCVA), applanation tonometry, slit-lamp biomicroscopic examination, color fundus photography, optical coherence tomography (OCT) and, if needed, fluorescein angiography. Overall, 224 anti-VEGF naïve subjects including 56 patients in early AMD group, 56 patients in intermediate AMD group, 56 patients in neovascular AMD group and 56 patients in no AMD group were recruited. For each group 28 male patients and 28 female patients were enrolled. IGF-1 hematic levels were significantly higher (p<0.005) in the neovascular AMD group and in the intermediate AMD group in comparison to no AMD group; no significant difference between early AMD group and no AMD group was found. Our analysis has shown an increment of IGF-1 levels in both neovascular and intermediate stage of AMD supporting the hypothesis that IGF-1 may play a role in the pathogenesis of AMD.

  

  IGF-1 levels in all patients, males and females, in four groups.

  
  
  

  

  Correlations between IGF-1 levels and age in four groups.

  
  
  

• Research Paper Volume 9, Issue 1 pp 133-141

  Association of neovascular age-related macular degeneration with month and season of birth in Italy

  Relevance score: 8.237008

  Antonio Longo, Alessandra Casuccio, Luca Pani, Teresio Avitabile, Salvatore Cillino, Maurizio G. Uva, Vincenza Bonfiglio, Andrea Russo, Guglielmo Parisi, Gilda Cennamo, Claudio Furino, Mariacristina Parravano, Entela Xoxi, Michele Reibaldi

  Keywords: neovascular age-related macular degeneration, neovascular AMD, anti-VEGF, season of birth, month of birth

  Published in Aging on December 19, 2016

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  In order to investigate the influence of season and month of birth on the risk of neovascular age-related macular degeneration (n-AMD) in Italy, we evaluated the month birth and sex of all patients, recorded in the anti-vascular endothelial growth factor (VEGF) monitoring registry of the Italian Medicines Agency, born between 1925–1944, who received intravitreal anti-VEGF injections for n-AMD between January 1, 2013 and July 29, 2015. The numbers of all births in Italy in the same years, extracted from the Italian National Institute of Statistics, were used to calculate the expected number of n-AMD cases. Overall, 45,845 patients (19,207 men, 26,638 women) received intravitreal anti-VEGF for n-AMD; in the same years, 20,140,426 people (10,334,262 male, 9,806,164 female) were born in Italy. Comparing the observed number of n-AMD cases with the expected number of n- AMD cases in each season, we found that the season-specific risk for n-AMD was 2.5% higher for those born in summer (OR=1.03, Bonferroni-corrected P=0.008) and 3% lower for those born in winter (OR=0.96, Bonferroni-corrected P=0.0004). When considering the month of birth, the risk of n-AMD was 5.9% lower for people born in January (OR=0.93, Bonferroni-corrected P=0.0012). The factors causing such differences should be determined.

  

  Pooled analysis of observed/expected births in people with neovascular AMD in Italy between 1925 and 1944 (n = 45845) with 95% confidence intervals.

  
  
  

  

  Odds ratios for people with neovascular AMD being born in different seasons in Italy between 1925 and 1944 (n = 45845) with 95% confidence intervals.

  
  
  

  

  Odds ratios for people with neovascular AMD being born in different months in Italy between 1925 and 1944 (n = 45845) with 95% confidence intervals.

  
  
  

  

  Odds ratios for men and women with neovascular AMD being born in different seasons in Italy between 1925 and 1944 (n = 45845) with 95% confidence intervals.

  
  
  

  

  Odds ratios for men and women with neovascular AMD being born in different months in Italy between 1925 and 1944 (n = 45845) with 95% confidence intervals.