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• Research Paper Volume 12, Issue 23 pp 23427-23435

  Evolution of COVID-19 in patients with autoimmune rheumatic diseases

  Relevance score: 13.327534

  Rongrong Pang, Jun Zhao, Zhenhua Gan, Zhiliang Hu, Xiang Xue, Yanjun Wu, Qinghua Qiao, Aifang Zhong, Xinyi Xia, Hui Liao, Zhihua Wang, Libo Zhang

  Keywords: coronavirus disease 2019, COVID-19, SARS-CoV-2 virus, autoimmune rheumatic diseases, systematic lupus erythematosus, rheumatoid arthritis

  Published in Aging on December 3, 2020

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  The characteristics of COVID-19 patients with autoimmune rheumatic diseases (AIRD) have rarely been reported. Patients with AIRD have suppressed immune defense function, which may increase their susceptibility to COVID-19. However, the immunosuppressive agents AIRD patients routinely used may be beneficial for protecting the cytokine storm caused by SARS-CoV-2. In this retrospective study, we included all confirmed cases in Huoshenshan Hospital from February 4 to April 9. Data were extracted from electronic medical records and were analyzed for clinical and laboratory features using SPSS (version 25.0). Of 3059 patients, 21 had the comorbidities with systematic lupus erythematosus (SLE) and/or rheumatoid arthritis (RA), including 5 with SLE, 15 with RA, and 1 with Rhupus. The proportion was 57.1% for severe cases, 61.9% for either severe or critical cases, and 4.8% for critical cases. The main manifestations, ARDS and ICU admission rate, as well as the mortality and length of hospital stay of COVID-19 in AIRD patients were similar to COVID-19 patients in the general population. Our preliminary experience shows that patients with AIRD tend to have a higher risk of SARS-CoV-2 infection, and may be at risk for a severe but less likely critical disease course. Further investigation is needed to understand the immunological features of these diseases.