About the Journal
Aims and ScopeIn aging research, evidence emerges that aging is controlled by genetic mechanisms involving signal transduction pathways highly conserved from yeast to mammals. Hyper-stimulation of certain signaling pathways drives the aging process and is involved in cell senescence and age-related disease. Modulation of DNA-damage response, sirtuins and stress-response, insulin-activated pathways, nutrient-sensing pathways, p53, FOXO and PTEN extends life span. And calorie restriction extends life span by modulating the same signaling pathways. This provides a potential means of pharmacologic intervention to extend life span and treat age-related diseases. Aging welcomes scientists in all disciplines, not only those in traditional gerontology.Aging publishes high-impact research papers of general interest and biological significance in all fields of aging research including but not limited to cellular senescence, DNA damage and repair, organismal aging, age-related diseases, genetic control of aging from yeast to mammals, regulation of longevity, evolution of aging, anti-aging strategies and drug development and especially the role of signal transduction pathways in aging and potential approaches to modulate these signaling pathways to extend lifespan.Aging covers (in addition to traditional topics on aging) many other topics including cellular and molecular biology (regulation of translation, cell growth, death and autophagy, mitochondria, DNA damage and repair, microRNAs, stem cells), human age-related diseases, pathology in model organisms, cancer and first of all signal transduction pathways (p53, sirtuins, PI-3K/AKT/mTOR and so on) and approaches to modulate these signaling pathways.
The Editorial Board
The Aging editorial board represents scientists from all over the world, predominantly from the USA. It includes six members of the National Academy of Sciences (USA), Lasker and Nobel Award recipients (Elizabeth H. Blackburn). It also includes the directors of some of the largest American cancer centers, directors of research from the most prominent pharmaceutical companies, professors from prestigious Universities, Editors of leading journals, and other prolific and distinguished scientists.
About Our Authors
We have published outstanding papers and reviews by Lawrence Donehower, Toren Finkel, Stephen Helfand, Gerald Shadel, Andre Nussenzweig, Maurice Burg, Karen Vousden, Leonard Guarente and other highly cited authors.Elizabeth Blackburn, a member of the Editorial Board of Aging, won the Nobel Prize in Physiology or Medicine 2009, while being a member of the Board. Elizabeth Blackburn co-authored a paper published in the first (inaugural) issue of Aging.Andrew V. Schally, Nobel Prize Laureate, published his paper in Aging.Shinya Yamanaka won the Nobel Prize in Physiology and Medicine 2012. Shinya Yamanaka co-authored paper published in Aging.