Review Volume 2, Issue 3 pp 122—128
Clock genes, hair growth and aging
- 1 Departments of Medicine and Biological Chemistry, University of California Irvine, Irvine CA 92697, USA
Received: March 12, 2010 Accepted: March 17, 2010 Published: March 18, 2010https://doi.org/10.18632/aging.100130
How to Cite
Hair follicles undergo continuous cycles of growth, involution and rest. This process, referred to as the hair growth cycle, has a periodicity of weeks to months. At the same time, skin and hair follicles harbor a functional circadian clock that regulates gene expression with a periodicity of approximately twenty four hours. In our recent study we found that circadian clock genes play a role in regulation of the hair growth cycle during synchronized hair follicle cycling, uncovering an unexpected connection between these two timing systems within skin. This work, therefore, indicates a role for circadian clock genes in a cyclical process of much longer periodicity than twenty four hours.