Review Volume 2, Issue 12 pp 900—907
The DNA damage response: Balancing the scale between cancer and ageing
- 1 Department of Systems, Biology, M. D. Anderson Cancer Center, Houston, TX 77054, USA
Received: September 8, 2010 Accepted: December 14, 2010 Published: December 16, 2010https://doi.org/10.18632/aging.100248
How to Cite
Defects in the DNA damage response often lead to an increased susceptibility to cancer, and so the DDR presents an interesting set of novel therapeutic targets. The maintenance of genomic integrity by the DDR has also been found to be involved in the process of organismal ageing. While the removal of cells containing damaged DNA can be beneficial in the prevention of cancer, it may contribute to both normal and pathological ageing.