Research Paper Volume 3, Issue 4 pp 391—394
Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster
- 1 Institute of Biology, Komi Scientific Center, Ural Branch, Russian Academy of Sciences, Syktyvkar, Russia
Received: March 24, 2011 Accepted: March 27, 2011 Published: March 28, 2011https://doi.org/10.18632/aging.100314
How to Cite
Aging is associated with NF-κB-dependent pro-inflammation. Here we demonstrated that inhibition of NF-κB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively.