Research Perspective Volume 3, Issue 5 pp 543—547
Interference between PARPs and SIRT1: a novel approach to healthy ageing?
- 1 Ecole Polytechnique Fédérale de Lausanne; CH-1015 Lausanne, Switzerland
Received: May 5, 2011 Accepted: May 6, 2011 Published: May 7, 2011https://doi.org/10.18632/aging.100326
How to Cite
Poly(ADP-ribosyl) polymerases (PARPs) have traditionally been linked to chromosome maintenance and DNA repair. Recent findings identify PARPs as key modulators of metabolism through their influence on SIRT1 activity, hinting to a possible role of PARPs as longevity regulators.