Research Perspective Volume 3, Issue 10 pp 913—919
Deciphering the role of Nuclear Factor-κB in cellular senescence
- 1 Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
received: September 15, 2011 ; accepted: September 25, 2011 ; published: September 26, 2011 ;https://doi.org/10.18632/aging.100390
How to Cite
Cellular senescence is a program of irreversible cell cycle arrest that cells undergo in response to a variety of intrinsic and extrinsic stimuli including progressive shortening of telomeres, changes in telomeric structure or other forms of genotoxic and non-genotoxic stress. The role of nuclear factor-κB in cellular senescence is controversial, as it has been associated with both proliferation and tumour progression, and also with growth arrest and ageing. This research perspective focuses on the evidence for a functional relationship between NF-κB and senescence, and how disruption of the NF-κB pathway can lead to its bypass.