Research Paper Volume 4, Issue 9 pp 580—589
Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians’ offspring
- 1 Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
- 2 IRCCS Istituto Auxologico Italiano, Milan, Italy
- 3 Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
- 4 Geriatric Unit IRCCS Ca' Granda Foundation Maggiore Policlinico Hospital, Milan, Italy
- 5 Dipartimento di Informatica, Sistemistica e Comunicazione, Universita' degli Studi di Milano Bicocca, Milan, Italy
- 6 Department of Experimental Pathology and Oncology, University of Florence, Florence, Italy
- 7 C.I.G. Interdepartmental Center “L. Galvani”, University of Bologna, Bologna, Italy
- 8 Department of Experimental Pathology, University of Bologna, Bologna, Italy
Received: June 28, 2012 Accepted: September 8, 2012 Published: September 9, 2012
https://doi.org/10.18632/aging.100484How to Cite
Abstract
Centenarians’ offspring represent a suitable model to study age-dependent variables (e.g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate the role of the IGF-I in human longevity. We evaluated circulating IGF-I bioactivity measured by an innovative IGF-I Kinase Receptor Activation (KIRA) Assay, total IGF-I, IGFBP-3, total IGF-II, insulin, glucose, HOMA2-B% and HOMA2-S% in 192 centenarians’ offspring and 80 offspring-controls of which both parents died relatively young. Both groups were well-matched for age, gender and BMI with the centenarians’ offspring. IGF-I bioactivity (p<0.01), total IGF-I (p<0.01) and the IGF-I/IGFBP-3 molar ratio (p<0.001) were significantly lower in centenarians’ offspring compared to offspring matched-controls. Serum insulin, glucose, HOMA2-B% and HOMA2-S% values were similar between both groups. In centenarians’ offspring IGF-I bioactivity was inversely associated to insulin sensitivity. In conclusion: 1) centenarians’ offspring had relatively lower circulating IGF-I bioactivity compared to offspring matched-controls; 2) IGF-I bioactivity in centenarians’ offspring was inversely related to insulin sensitivity. These data support a role of the IGF-I/insulin system in the modulation of human aging process.