Research Paper Volume 4, Issue 10 pp 686—694
The mitochondria-targeted antioxidant SkQ1 but not N-acetylcysteine reverses aging-related biomarkers in rats
- 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia
- 2 Institute of Mitoengineering, Moscow, Russia
- 3 Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology, Moscow, Russia
Received: August 21, 2012 Accepted: October 27, 2012 Published: October 28, 2012https://doi.org/10.18632/aging.100493
How to Cite
Although antioxidants have been repeatedly tested in animal models and clinical studies, there is no evidence that antioxidants reduce already developed age-related decline. Recently we demonstrated that mitochondria-targeted antioxidant 10-(6'-plastoquinonyl) decyltriphenylphosphonium (SkQ1) delayed some manifestations of aging. Here we compared effects of SkQ1 and N-acetyl-L-cysteine (NAC) on age-dependent decline in blood levels of leukocytes, growth hormone (GH), insulin-like growth factor-1 (IGF-1), testosterone, dehydroepiandrosterone (DHEA) in Wistar and senescence-accelerated OXYS rats. When started late in life, supplementation with SkQ1 not only prevented age-related decline but also significantly reversed it. With NAC, all the observed effects were of the lower magnitude compared with SkQ1 (in spite of that dose of NAC was 16000 times higher). We suggest that supplementation with low doses of SkQ1 is a promising intervention to achieve a healthy ageing.