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Meeting Report|Volume 5, Issue 1|pp 84—93

The role of inflammation in age-related disease

T. Kevin Howcroft1, Judith Campisi2, Germaine Buck Louis3, Martyn T. Smith4, Bradley Wise5, Tony Wyss-Coray6, Alison Deckhut Augustine7, Janet E. McElhaney8, Ron Kohanski9, Felipe Sierra9
  • 1Division of Cancer Biology, NCI, NIH, Bethesda, MD 20892, USA
  • 2Buck Institute for Research on Aging, Novato, CA 94945, USA and Lawrence Berkeley National Laboratory, Berkeley, CA 94702 USA
  • 3Office of the Director, NICHD, NIH, Bethesda, MD 20892, USA
  • 4Division of Environmental Health Sciences, University of California, Berkeley, CA 94720, USA
  • 5Division of Neuroscience, NIA, NIH, Bethesda, MD 20892, USA
  • 6Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305
  • 7Division of Allergy, Immunology and Transplantation, NIAID, NIH, Bethesda, MD 20892, USA
  • 8Advanced Medical Research Institute of Canada, Sudbury, ON, P3E 5J1, Canada
  • 9Division of Aging Biology, NIA, NIH, Bethesda, MD 20892, USA
Received: January 26, 2012Accepted: January 29, 2013Published: January 30, 2013
https://doi.org/10.18632/aging.100531

Copyright: © 2013 Howcroft et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The National Institutes of Health (NIH) Geroscience Interest Group (GSIG) sponsored workshop, The Role of Inflammation in Age-Related Disease, was held September 6th-7th, 2012 in Bethesda, MD. It is now recognized that a mild pro-inflammatory state is correlated with the major degenerative diseases of the elderly. The focus of the workshop was to better understand the origins and consequences of this low level chronic inflammation in order to design appropriate interventional studies aimed at improving healthspan. Four sessions explored the intrinsic, environmental exposures and immune pathways by which chronic inflammation are generated, sustained, and lead to age-associated diseases. At the conclusion of the workshop recommendations to accelerate progress toward understanding the mechanistic bases of chronic disease were identified.