Research Perspective Volume 6, Issue 2 pp 92—97
Hypothalamic-mediated control of glucose balance in the presence and absence of insulin
- 1 Department of Internal Medicine, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
- 2 Department of Cellular Physiology and Metabolism, University of Geneva, Geneva 1211, Switzerland
Received: February 19, 2014 Accepted: February 28, 2014 Published: March 2, 2014
https://doi.org/10.18632/aging.100641How to Cite
Abstract
Diabetes afflicts hundreds of millions worldwide. People affected by type 1 diabetes mellitus (T1DM; the insulin-deficient form of diabetes) or type 2 diabetes mellitus (T2DM; the insulin-resistant form of diabetes) have significantly reduced life expectancy compared to normal individuals. This is due in part to the fact that (despite improvements) current anti-diabetic approaches are suboptimal. Indeed, severe morbidities (e.g.: cardiovascular disease, hypertension) are still too often associated with diabetes. Recent preclinical results indicate that different types of hypothalamic neurons are endowed with the ability to mediate the hyperglycemia-lowering action of the adipocyte-derived hormone leptin in an insulin-dependent and insulin-independent fashion. These results may pave the way for better anti-diabetic approaches and therefore positively impact on life expectancy of diabetic subjects