Review Volume 7, Issue 10 pp 754—765
Systemic Problems: A perspective on stem cell aging and rejuvenation
- 1 Department of Bioengineering, UC Berkeley; QB3, CA 94709, USA
received: August 5, 2015 ; accepted: October 2, 2015 ; published: October 25, 2015 ;https://doi.org/10.18632/aging.100819
How to Cite
This review provides balanced analysis of the advances in systemic regulation of young and old tissue stem cells and suggests strategies for accelerating development of therapies to broadly combat age-related tissue degenerative pathologies. Many highlighted recent reports on systemic tissue rejuvenation combine parabiosis with a “silver bullet” putatively responsible for the positive effects. Attempts to unify these papers reflect the excitement about this experimental approach and add value in reproducing previous work. At the same time, defined molecular approaches, which are “beyond parabiosis” for the rejuvenation of multiple old organs represent progress toward attenuating or even reversing human tissue aging.