Review Volume 8, Issue 1 pp 3—11
Markers of cellular senescence. Telomere shortening as a marker of cellular senescence
- 1 Karolinska Institute, Department of Medical Biochemistry and Biophysics, Stockholm, 14157, Sweden
- 2 St. Petersburg Institute of Bioregulation and Gerontology, Russian Academy of Sciences, Saint-Petersburg, 197110 Russia
- 3 Institute of Cytology, Russian Academy of Sciences, Saint-Petersburg, 194064, Russia
- 4 Saint-Petersburg's State University, Saint-Petersburg, 199034, Russia
- 5 Saint-Petersburg's Polytechnic State University, Saint-Petersburg, 195251 Russia
Received: December 12, 2014 Accepted: January 18, 2016 Published: January 23, 2016
https://doi.org/10.18632/aging.100871How to Cite
Abstract
The cellular senescence definition comes to the fact of cells irreversible proliferation disability. Besides the cell cycle arrest, senescent cells go through some morphological, biochemical, and functional changes which are the signs of cellular senescence. The senescent cells (including replicative senescence and stress-induced premature senescence) of all the tissues look alike. They are metabolically active and possess the set of characteristics in vitro and in vivo, which are known as biomarkers of aging and cellular senescence. Among biomarkers of cellular senescence telomere shortening is a rather elegant frequently used biomarker. Validity of telomere shortening as a marker for cellular senescence is based on theoretical and experimental data.