Research Paper Volume 9, Issue 2 pp 475—486
Long intergenic non-protein coding RNA 00858 functions as a competing endogenous RNA for miR-422a to facilitate the cell growth in non-small cell lung cancer
- 1 Department of Cardiothoracic Surgery, ZhongNan Hospital of Wuhan University, 430071 Wuhan, P. R. China
- 2 Department of Oncology, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, 430015 Wuhan, P. R. China
received: November 27, 2016 ; accepted: January 31, 2017 ; published: February 6, 2017 ;https://doi.org/10.18632/aging.101171
How to Cite
The expression of long non-coding RNAs (lncRNAs) is dysregulated in non-small cell lung cancer (NSCLC). However, the functions and contributions of lncRNAs remain largely unknown. Here, we identified a critical role of long intergenic non-protein coding RNA 00858 (LINC00858) in NSCLC. Ectopic expression of LINC00858 in NSCLC cells promoted cell proliferation and induced cell migration and invasion. Moreover, LINC00858 functioned as a competitive endogenous RNA (ceRNA), effectively becoming sponge for miR-422a and thereby modulating the expression of kallikrein-related peptidase 4 (KLK4). In NSCLC patients, high expression of LINC00858 closely correlated with tumor progression. Thus, targeting the ceRNA network involving LINC00858 may be used as a treatment strategy against NSCLC.