Cluster | Gene names | Size | Count | Odds Ratio | p-value | Deregulation |
Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | ADCY1, CHRM1, CHRM3, GNAI3, MCHR1, GRM8, HTR1B, HTR1E, HTR1F, NPY1R, OPRK1, OPRM1, SSTR2 | 64 | 13 | 3.79 | 0.000164 | Up |
Astrocyte differentiation | ABL1, MAG, NKX2-2, NOTCH1, POU3F2, S100B, TAL1, CNTN2, SOX8 | 53 | 9 | 5.12 | 0.000184 | Down |
Axolemma | KCNC1, KCNC2, KCNH1, ROBO2, SLC1A2 | 14 | 5 | 8.26 | 0.00124 | Up |
Axon | DAGLA, CAMK2D, CCK, CHRM1, CHRM3, AP1S1, CTNNA2, DLG4, DRD1, EPHA4, PTK2B, FGF13, GAP43, GARS, GRIA1, GRIK5, GRIN2A, HTR2A, KCNB1, KCNC1, KCNC2, KCNH1, KCNK2, KCNMA1, KCNQ2, KCNQ3, MYH10, NPY1R, NRCAM, NRGN, OPRK1, PAK1, PFN2, MAP2K1, PTPRN2, ROBO2, SCN1A, SCN1B, SCN2A, SCN8A, CCL2, SLC1A2, SNCA, STXBP1, SYN1, KCNAB1, FZD3, GLRA3, PRSS12, CNTNAP1, KCNAB2, NRP1, CDK5R1, BSN, SYT7, SYNGR1, DGKI, NRXN1, HOMER1, KATNB1, SEMA3A, OLFM1, SLC9A6, CPLX1, AAK1, ADGRL1, TPX2, UNC13A, MYCBP2, NCS1, PACSIN1, STMN3, SEPT11, SLC17A7, TBC1D24, NDEL1, LMTK3, MTPN, CNTN4, LRRTM1, HCN1 | 358 | 81 | 4.6 | 1.68e-24 | Up |
Axon extension | BMPR2, NRCAM, PPP3CB, SLIT1, CDKL5, NRP1, CDK5R1, LHX2, SEMA3A, OLFM1, SLC9A6, BCL11A, ISLR2, NDEL1 | 91 | 14 | 2.7 | 0.00176 | Up |
Axon hillock | CCK, TPX2, NDEL1 | 7 | 3 | 11.1 | 0.00729 | Up |
Cadherin binding | CDH13, CTNNA2, TRPC4, CDK5R1, AKAP5, MMP24, PTPRT | 29 | 7 | 4.81 | 0.00167 | Up |
Calcineurin complex | ITPR1, PPP3CA, PPP3CB, PPP3R1 | 4 | 4 | Inf | 1.59e-05 | Up |
Calcium channel regulator activity | CACNB2, FKBP1B, ITPR1, PRKCB, STX1A, NRXN1, TSPAN13, HPCAL4, CACNA2D3 | 36 | 9 | 5.05 | 0.000281 | Up |
Calcium ion-dependent exocytosis of neurotransmitter | CACNA1A, SYT1, SYT5, DOC2A, SYT7, RIMS2, RAB3GAP1, RIMS1, SYT13, SYT12 | 28 | 10 | 8.25 | 4.76e-06 | Up |
Calmodulin binding | ADCY1, ADD2, ATP2B1, ATP2B2, CACNA1C, CAMK4, CAMK2A, CAMK2B, CAMK2D, GAP43, ITPKA, KCNH1, KCNN1, KCNQ3, MAP2, MYH10, MYO5A, NOS2, NRGN, PDE1B, PPP3CA, PPP3CB, PPP3R1, RGS4, RIT2, RYR2, SLC8A2, SLC8A1, AKAP5, CAMKK2, ARPP21, PLCB1, KCNH5, CAMK1D, CAMK1G, CAMKV, CAMKK1, PNCK, CFAP221, RIIAD1 | 176 | 40 | 4.57 | 5.38e-13 | Up |
Calmodulin-dependent protein kinase activity | CAMK4, CAMK2A, CAMK2B, CAMK2D, PTK2B, ITPKA, CAMKK2, CAMK1D, CAMK1G, CAMKK1, PNCK | 32 | 11 | 7.95 | 2.02e-06 | Up |
Camp binding | PDE2A, PDE4A, PRKAR1B, PRKAR2B, RAPGEF2, RAPGEF4, HCN1 | 24 | 7 | 6.23 | 0.000487 | Up |
Central nervous system neuron axonogenesis | EPHA4, SCN1B, NR2E1, MYCBP2, PRDM8, ARHGEF28, NDEL1 | 29 | 7 | 4.71 | 0.00187 | Up |
Chloride channel activity | CLIC2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRB2, GABRB3, GABRD, GABRG3, GLRB, SLC26A4, GLRA3, SLC17A7, SLC26A8, ANO5 | 78 | 16 | 3.93 | 2.05e-05 | Up |
Clathrin binding | SYT1, SYT5, DOC2A, SYT7, SNAP91, HMP19, SYTL2, CEMIP, SYT13, SMAP1, SYT16, SYT12 | 56 | 12 | 4.14 | 0.000141 | Up |
Compact myelin | MAG, SIRT2, JAM3 | 12 | 3 | 8.38 | 0.00957 | Down |
Cyclin-dependent protein serine/threonine kinase activity | CDK14, CDKL5, CDKL1, CDK5R1, CDKL2, CDK20 | 29 | 6 | 3.94 | 0.008 | Up |
Cytoskeleton of presynaptic active zone | BSN, PCLO | 2 | 2 | Inf | 0.004 | Up |
Dendrite | BMPR2, CACNA1A, CACNA1B, CACNA1C, CCK, CHRM1, CHRM3, CRMP1, DLG3, DLG4, DRD1, EPHA4, EPHA7, PTK2B, FGF13, GABRA5, GRIA1, GRIA2, GRIA3, GRIK5, GRIN2A, GRM1, GRM5, HTR2A, ITPKA, KCNB1, KCNC1, KCNC2, KCND3, KCNH1, KCNJ4, KCNQ3, MAP2, MYH10, NELL2, NRGN, OPRK1, PAK1, PRKAR2B, PRKCG, MAP2K1, RARA, RGS7, SCN8A, CCL2, SLC8A1, CDKL5, SYN1, KCNAB1, FZD3, PRSS12, CDK5R1, BSN, NEURL1, DGKI, HOMER1, CABP1, AKAP5, ARHGAP32, FRMPD4, SEMA3A, BAIAP2, SLC9A6, ARFGEF2, CHL1, PLK2, CPLX1, LZTS1, CPEB3, NCS1, NSMF, SHANK1, IFT57, SEPT11, ANKS1B, SLC4A10, TENM2, DLGAP3, JPH4, PPP1R9B, SHANK3, LMTK3, GRIN3A, SNAP47, CNIH2, HCN1 | 406 | 86 | 4.24 | 7.25e-24 | Up |
Dendrite development | ADGRB3, CACNA1A, CAMK2B, CTNNA2, DLG4, EPHA4, HPRT1, ITPKA, MAP2, MEF2C, PAK1, PAK3, PPP3CA, CDKL5, NR2E1, NRP1, CDK5R1, NEURL1, AKAP5, RAPGEF2, KIAA0319, SEMA3A, BAIAP2, SLC9A6, PLK2, CIT, LZTS1, CPEB3, NEDD4L, MAPK8IP2, RBFOX2, NGEF, NSMF, SLITRK5, PACSIN1, SHANK1, DCDC2, BCL11A, FEZF2, CAMK1D, SHANK3, GRIN3A, FMN1 | 178 | 43 | 4.85 | 1.44e-14 | Up |
Dendrite extension | PARK2, SYT1, RIMS2, SLC9A6, RIMS1, UNC13A, NEDD4L, CPNE5 | 21 | 8 | 9.12 | 2.53e-05 | Up |
Dendrite morphogenesis | ADGRB3, CACNA1A, CAMK2B, CTNNA2, DLG4, EPHA4, HPRT1, ITPKA, MAP2, PAK3, PPP3CA, CDKL5, NR2E1, CDK5R1, AKAP5, RAPGEF2, SEMA3A, BAIAP2, CIT, LZTS1, NEDD4L, MAPK8IP2, RBFOX2, NGEF, NSMF, SLITRK5, SHANK1, DCDC2, SHANK3, FMN1 | 109 | 30 | 5.73 | 4E-12 | Up |
Dendritic shaft | CACNA1C, DLG3, DRD1, GRM5, HTR2A, MAP2, PRKAR2B, SLC8A1, HOMER1, AKAP5, LZTS1, JPH4, CNIH2 | 37 | 13 | 8.11 | 2.07e-07 | Up |
Dendritic spine development | CAMK2B, DLG4, EPHA4, ITPKA, MEF2C, PAK1, PAK3, CDK5R1, NEURL1, BAIAP2, SLC9A6, PLK2, CPEB3, NGEF, SHANK1, SHANK3 | 58 | 16 | 5.68 | 4.06e-07 | Up |
Dendritic spine membrane | ATP2B1, GRIA1, ITGA8, AKAP5, DDN | 9 | 5 | 18.6 | 0.000102 | Up |
DNA metabolic process | BMPR2, CDKN2D, CIDEA, DACH1, HGF, IGF1, KCNK2, KPNA2, MAS1, KITLG, ORC4, PAK3, PIK3CA, PRKCG, CHAF1B, CDC7, NPM2, PPARGC1A, PARM1, CHD5, UBE2W, FBXW7, TSPYL2, BCL11B, SLF1, TBRG1, MAEL, XRCC6BP1, ZBED9, KLHDC3, STOX1, KIAA2022 | 867 | 32 | 0.549 | 0.000264 | Up |
Ensheathment of neurons | MYRF, LPAR1, KCNJ10, KEL, MAG, MAL, NGFR, CLDN11, PMP22, POU3F2, KLK6, CNTN2, QKI, ARHGEF10, OLIG2, NDRG1, SIRT2, PARD3, FA2H, SH3TC2, JAM3, NKX6-2, SERINC5 | 101 | 23 | 7.53 | 4.57e-12 | Down |
Excitatory postsynaptic potential | DLG4, PTK2B, GRIK5, GRIN2A, GRIN2B, MEF2C, PPP3CA, SNCA, STX1A, DGKI, NRXN1, RIMS2, RAB3GAP1, RIMS1, MAPK8IP2, SHANK1, CELF4, SLC17A7, NETO1, SHANK3 | 50 | 20 | 9.99 | 7.46e-12 | Up |
GABA receptor activity | GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRB2, GABRB3, GABRD, GABRG3, GABBR2 | 22 | 10 | 12.6 | 2.77e-07 | Up |
GABA receptor binding | GABRA5, AKAP5, ARFGEF2, JAKMIP1 | 14 | 4 | 6.03 | 0.0091 | Up |
Glial cell development | MYRF, GSN, KCNJ10, NKX2-2, POU3F2, CNTN2, ARHGEF10, NDRG1, SIRT2, PHGDH, PARD3, FA2H, SH3TC2, NKX6-2 | 71 | 14 | 6.19 | 4.84e-07 | Down |
Glutamate receptor activity | PTK2B, GRIA1, GRIA2, GRIA3, GRIK5, GRIN2A, GRIN2B, GRM1, GRM5, GRM8, GRIN3A | 27 | 11 | 10.4 | 2.72e-07 | Up |
Innervation | GABRA5, GABRB2, GABRB3, PRKCG, NRP1, SEMA3A, UNC13A | 23 | 7 | 6.47 | 0.000412 | Up |
Inositol phosphate metabolic process | PTK2B, ITPKA, MAS1, OCRL, SNCA, INPP4B, SYNJ1, PPIP5K1, PLCH1, PLCB1, NUDT11 | 65 | 11 | 3.02 | 0.00247 | Up |
Ionotropic glutamate receptor activity | PTK2B, GRIA1, GRIA2, GRIA3, GRIK5, GRIN2A, GRIN2B, GRIN3A | 19 | 8 | 11 | 9.08e-06 | Up |
JNK cascade | ADORA2B, EPHA4, PTK2B, FGF14, MAP3K9, MAP3K10, GADD45B, PAK1, PARK2, MAPK9, CCL19, MAP2K4, MAP3K6, RB1CC1, RASGRP1, PLCB1, MAPK8IP2, KIAA1804, DUSP19, ZNF675, MAGI3 | 185 | 21 | 1.9 | 0.00716 | Up |
Lipid binding | ABCA1, ANXA5, APOD, AR, C3, LPAR1, HSD17B10, HIP1, HSPA2, KCNJ2, MAL, MYO1E, NPC1, P2RX7, PLD1, PTGS1, SELL, SNX1, ACOX2, IQGAP1, HIP1R, CYTH1, STARD3, FNBP1, RASGRP3, LDLRAP1, GLTP, ANKFY1, PXK, ADAP2, PARD3, PREX1, WDFY4, PLEKHF1, PRAM1, PAQR8, MVB12B, SNX29, SYTL4, ARAP1, FRMPD2, AMER2, NCF1C, C8orf44-SGK3 | 601 | 44 | 2.07 | 2.63e-05 | Down |
Mrna processing | LGALS3, CELF2, PPARGC1A, CELF3, CPEB3, RBFOX2, RBFOX1, MTPAP, CELF4, CELF5, SRRM4, LSM11, RBFOX3 | 417 | 13 | 0.466 | 0.00202 | Up |
Myelin maintenance | MYRF, NDRG1, FA2H, SH3TC2 | 11 | 4 | 14.2 | 0.000601 | Down |
Myelin sheath | CA2, CNP, CRYAB, GSN, HSPA2, MAG, MOBP, MOG, MYO1D, CLDN11, RDX, CNTN2, NDRG1, SIRT2, PHGDH, GJC2, ERMN, MYH14, JAM3, SERINC5 | 156 | 20 | 3.77 | 2.29e-06 | Down |
Myelination | MYRF, LPAR1, KCNJ10, KEL, MAG, MAL, NGFR, PMP22, POU3F2, KLK6, CNTN2, QKI, ARHGEF10, OLIG2, NDRG1, SIRT2, PARD3, FA2H, SH3TC2, JAM3, NKX6-2, SERINC5 | 98 | 22 | 7.38 | 1.81e-11 | Down |
Negative regulation of neuron apoptotic process | CACNA1A, PTK2B, GABRA5, GABRB2, GABRB3, MEF2C, PARK2, PIK3CA, PRKCG, CCL2, SNCB, SNCA, STAR, STXBP1, NRP1, CHL1, PPARGC1A, OXR1, AGAP2 | 128 | 19 | 2.59 | 0.000465 | Up |
Negative regulation of transcription, DNA-templated | ARNTL, RUNX1T1, CRYM, CYP1B1, DACH1, FGF9, FOXG1, H2AFZ, MEF2C, MAP3K10, TRIM37, PDE2A, RARA, RORB, SATB1, SNCA, SOX5, TBX15, THRB, NR2E1, WNT10B, CDK5R1, LRRFIP1, ZBTB33, BASP1, ZBTB18, KLF12, CPEB3, PLCB1, SATB2, NEDD4L, SIRT5, RBFOX2, ATAD2, TAGLN3, BCL11A, FEZF2, SMYD2, PRDM8, TENM2, MTA3, SCRT1, MAEL, PRICKLE1, EID2, ARX, ZNF675, KCTD1 | 1135 | 48 | 0.632 | 0.00083 | Up |
Neuron apoptotic process | CACNA1A, EPHA7, PTK2B, GABRA5, GABRB2, GABRB3, GRIK5, KCNB1, MEF2C, PAK3, PARK2, PIK3CA, PRKCG, SCN2A, CCL2, SNCB, SNCA, STAR, STXBP1, NRP1, CDK5R1, CHL1, PPARGC1A, NSMF, OXR1, FBXW7, AGAP2, SDIM1 | 206 | 28 | 2.35 | 0.000117 | Up |
Neuron spine | DLG4, DRD1, EPHA4, GRIA1, GRM5, ITPKA, MYH10, NRGN, PRKAR2B, SLC8A1, CDK5R1, NEURL1, DGKI, AKAP5, ARHGAP32, FRMPD4, BAIAP2, SLC9A6, ARFGEF2, LZTS1, SHANK1, SEPT11, ANKS1B, TENM2, DLGAP3, PPP1R9B, SHANK3, CNIH2 | 104 | 28 | 5.57 | 3.28e-11 | Up |
Neuronal postsynaptic density | ADD2, ATP1A1, BMPR2, CAMK2A, CAMK2B, CTNNA2, DLG4, DMTN, GAP43, GRIN2B, MAP2, PAK1, PRKCG, BSN, DGKI, DLGAP1, HOMER1, BAIAP2, CAP2, CNKSR2, CLSTN1, MAPK8IP2, SHANK1, CLSTN2, SHANK3 | 64 | 25 | 9.69 | 3.02e-14 | Up |
Neuron-neuron synaptic transmission | CA7, CACNA1A, CACNB4, CAMK4, DRD1, PTK2B, GABRA1, GABRB2, GLRB, GRIA1, GRIA2, GRIA3, GRIK5, GRIN2A, GRM1, GRM5, GRM8, HRH2, HTR1B, HTR2A, MEF2C, NPY5R, PAK1, PARK2, PRKCE, PTGS2, SNCA, STXBP1, SYT1, GLRA3, DGKI, DLGAP2, NRXN1, RAB3GAP1, UNC13A, MAPK8IP2, RASD2, TMOD2, SHC3, SLC17A7, SHANK3, GRIN3A, CNIH2 | 136 | 43 | 7.06 | 2.63e-19 | Up |
Neurotransmitter secretion | CACNA1A, CACNA1B, CAMK2A, GAD1, GLS, GRIK5, MEF2C, PAK1, PARK2, PFN2, SLC1A1, SLC1A2, SNCA, STX1A, STXBP1, SYN1, SYN2, SYT1, SYT5, DOC2A, PPFIA4, PPFIA2, PPFIA3, CADPS, LIN7A, SYNJ1, SYT7, DGKI, BZRAP1, NRXN1, RIMS2, RIMS3, CPLX1, HRH3, ADGRL1, RAB3GAP1, RIMS1, UNC13A, PCLO, SYTL2, SLC17A7, SYT13, SYT16, SYT12, CADPS2, SNAP47 | 154 | 46 | 6.52 | 1.93e-19 | Up |
Node of Ranvier | KCNQ2, KCNQ3, SCN1A, SCN1B, SCN2A, SCN8A | 15 | 6 | 9.92 | 0.000193 | Up |
Nucleic acid metabolic process | ABCA2, ABL1, PARP4, AR, ATM, BMP8B, MYRF, CAPN3, CAT, CBFB, CCNA2, CDKN1C, CENPB, ELF1, EYA4, ERF, FGF1, FGFR2, GDF1, HSD17B10, HDAC1, HIP1, HOXA1, HOXA2, HOXA5, HOXB2, HOXB5, HOXD1, HOXD3, HSPA1A, FOXN2, JUP, SMAD5, SMAD9, MCM7, MEIS1, CIITA, FOXO4, NKX2-2, NOTCH1, YBX1, PBX3, PDE8A, ENPP2, POLR2L, POU3F2, PSEN1, RNH1, RPLP0, RPS5, RXRG, SALL1, SGK1, SOX10, SREBF1, STAT2, SYK, TAL1, TCF12, TRAF1, TRPS1, ZNF3, ZNF69, VEZF1, FZD5, ARHGEF5, HIST1H2AC, HIST1H3E, HIST1H4H, HIST1H4B, RNASET2, CCNE2, QKI, LITAF, ST18, ZNF536, DDX39A, OLIG2, HMG20B, SEMA4D, TXNIP, DMRT2, TCFL5, ATF7, IKZF2, ZNF652, SIRT2, SAMD4A, KANK1, HEY2, BAMBI, ZNF521, ZBTB20, GREM1, CECR2, HIPK2, KLF15, BAZ2B, SLC40A1, SOX8, ZBTB7B, RRNAD1, KLF3, DDIT4, ZNF280D, TRIM62, CHD7, SLF2, ZNF83, SLC2A4RG, OTUD7B, BBX, MAVS, SFMBT2, NCOA5, TP53INP2, ZNF462, ARHGAP22, CREB3L2, CRTC3, TRAK2, BHLHE41, DBF4B, TSC22D4, NKX6-2, ZBTB37, LOXL3, OLIG1, ZSWIM7, GABPB2, CC2D1B, ZBTB12, ZNF844, ZNF326, FRYL, C9orf142, ZNF710, GTF2IRD2B, DBX2, HIST2H4B, ZNF812, TMEM229A, GTF2H2C_2, C8orf44-SGK3 | 4679 | 144 | 0.718 | 0.000284 | Up |
Oligodendrocyte development | MYRF, GSN, KCNJ10, NKX2-2, CNTN2, FA2H, NKX6-2 | 32 | 7 | 6.99 | 0.000187 | Down |
Oligodendrocyte differentiation | BOK, MYRF, CNP, GSN, KCNJ10, NKX2-2, NOTCH1, SOX10, CNTN2, OLIG2, SOX8, FA2H, NKX6-2 | 75 | 13 | 5.27 | 5.64e-06 | Down |
Phosphatase activity | ALPL, ATP1A1, CDKN3, DUSP8, OCRL, PPP2R5D, PPP3CA, PPP3CB, PPP3R1, MAP2K1, PTPN3, PTPN4, PTPRN2, PTPRR, INPP4B, SYNJ1, PPIP5K1, LPPR4, PTPRT, PTP4A3, NT5DC3, PDP1, LPPR3, PTPN5, DUSP19, PPM1L, PPM1J | 254 | 27 | 1.81 | 0.00475 | Up |
Phosphatidylinositol binding | HIP1, KCNJ2, MYO1E, PLD1, SNX1, IQGAP1, HIP1R, LDLRAP1, ANKFY1, PXK, ADAP2, PARD3, PLEKHF1, SNX29, ARAP1, FRMPD2, AMER2, NCF1C, C8orf44-SGK3 | 187 | 19 | 2.92 | 9.82e-05 | Down |
Phospholipase C-activating G-protein coupled receptor signaling pathway | ADRA1B, CCKBR, CHRM1, CHRM3, DRD1, GRM1, GRM5, HRH2, HTR2A, OPRK1, OPRM1, HOMER1, MCHR2 | 81 | 13 | 2.84 | 0.00172 | Up |
Phospholipid binding | ABCA1, ANXA5, LPAR1, HIP1, KCNJ2, MYO1E, PLD1, SNX1, IQGAP1, HIP1R, LDLRAP1, ANKFY1, PXK, ADAP2, PARD3, PREX1, WDFY4, PLEKHF1, SNX29, SYTL4, ARAP1, FRMPD2, AMER2, NCF1C, C8orf44-SGK3 | 332 | 25 | 2.1 | 0.000966 | Down |
Phospholipid translocation | ABCA1, P2RX7, ATP10B, ATP11A | 20 | 4 | 6.21 | 0.00667 | Down |
Positive regulation of RNA metabolic process | ACVR1B, ARNTL, BMPR2, CAMK4, CAMK2A, CDH13, ETV1, H2AFZ, HGF, IGF1, KRAS, LUM, MEF2C, TRIM37, PPP1R12A, NEUROD2, PARK2, PLAGL1, PPP3CA, PPP3CB, PPP3R1, PRKCB, MAPK9, MAP2K1, RARA, RORB, SOX5, STAT4, THRB, NR2E1, TRAF5, WNT10B, ITGA8, LMO4, LDB2, LHX2, MICAL2, CAMKK2, TBR1, PPARGC1A, MLLT11, CELF3, KLF12, CPEB3, MAPRE3, DDN, PLCB1, SATB2, ATAD2, BCL11A, TESC, FEZF2, FBXW7, DCAF6, CELF4, ARNTL2, ATXN7L3, CAMK1D, MKL2, NEUROD6, BCL11B, CSRNP3, MED12L, RHEBL1, MTPN, SOHLH1 | 1455 | 66 | 0.678 | 0.0011 | Up |
Postsynapse | ADD2, ATP1A1, BMPR2, CACNA1C, CAMK2A, CAMK2B, CHRM1, CHRM3, CTNNA2, DLG3, DLG4, DRD1, DMTN, EPHA4, EPHA7, PTK2B, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRB2, GABRB3, GABRD, GABRG3, GAP43, GLRB, GRIA1, GRIA2, GRIA3, GRIK5, GRIN2A, GRIN2B, GRM1, GRM5, ITPKA, ITPR1, KCNB1, KCNC2, KCNJ4, KCNMA1, MAP2, MYH10, NRGN, PAK1, PRKAR2B, PRKCG, SLC8A1, GLRA3, KCNAB2, ITGA8, LIN7A, CDK5R1, BSN, NEURL1, DGKI, DLGAP2, DLGAP1, HOMER1, CABP1, AKAP5, GABBR2, ARHGAP32, FRMPD4, LZTS3, BAIAP2, CAP2, ARFGEF2, LZTS1, CNKSR2, CLSTN1, RIMS1, SYNE1, NCS1, MAPK8IP2, NSMF, PCLO, SHANK1, SEPT11, ANKS1B, TENM2, LRFN2, KCTD16, LRRC7, DLGAP3, CACNG8, CLSTN2, LRRTM4, NETO1, PPP1R9B, SHANK3, CADPS2, GRIN3A, GRASP, CNIH2, LRRTM1, LRRTM3, IQSEC3 | 341 | 98 | 6.47 | 7.81e-39 | Up |
Postsynaptic membrane | CHRM1, CHRM3, DLG3, DLG4, EPHA4, EPHA7, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRB2, GABRB3, GABRD, GABRG3, GLRB, GRIA1, GRIA2, GRIA3, GRIK5, GRIN2A, GRIN2B, KCNB1, KCNC2, KCNJ4, KCNMA1, GLRA3, LIN7A, NEURL1, DLGAP2, DLGAP1, HOMER1, CABP1, GABBR2, ARHGAP32, LZTS3, LZTS1, CNKSR2, CLSTN1, SYNE1, NCS1, NSMF, SHANK1, ANKS1B, TENM2, LRFN2, KCTD16, LRRC7, DLGAP3, CACNG8, CLSTN2, LRRTM4, NETO1, SHANK3, CADPS2, GRIN3A, GRASP, CNIH2, LRRTM1, LRRTM3, IQSEC3 | 197 | 61 | 6.98 | 1.99e-26 | Up |
Potassium channel activity | KCNB1, KCNC1, KCNC2, KCND3, KCNF1, KCNH1, KCNJ3, KCNJ4, KCNJ6, KCNJ9, KCNK2, KCNMA1, KCNN1, KCNQ2, KCNQ3, KCNS1, KCNS2, KCNAB1, KCNAB2, KCNAB3, KCNH4, KCNH3, KCNV1, KCNH5, KCNIP2, KCNQ5, KCNT1, KCNK15, KCNIP4, KCNH7, KCNG3, KCNT2, HCN1 | 119 | 33 | 5.93 | 1.53e-13 | Up |
Presynapse | DLG4, GABRA2, GRIA1, GRIA2, GRIN2B, ICA1, NPY1R, SNCA, STX1A, SYN1, SYN2, SYT1, SYT5, SLC30A3, FZD3, DOC2A, PPFIA4, PPFIA2, PPFIA3, BSN, SYT7, SYNGR1, DGKI, RIMS2, RIMS3, SV2B, DNM1L, RIMS1, UNC13A, DMXL2, ERC2, PCLO, SVOP, SLC17A7, SYT12, TPRG1L, SYNPR, STXBP5, SCAMP5, SLC6A17, UNC13C | 142 | 41 | 6.21 | 5.89e-17 | Up |
Presynaptic active zone | SYN1, FZD3, PPFIA4, PPFIA2, PPFIA3, BSN, DGKI, RIMS2, RIMS3, RIMS1, UNC13A, ERC2, PCLO, SLC17A7, UNC13C | 24 | 15 | 25 | 7.23e-13 | Up |
Protein kinase C-activating G-protein coupled receptor signaling pathway | CCK, CHRM1, DGKB, GAP43, GRM1, GRM5, HTR1B, DGKZ, DGKE, DGKI | 32 | 10 | 6.74 | 1.85e-05 | Up |
Protein lipidation | ABCA1, ZDHHC9, PIGT, HHATL, ZDHHC14, ZDHHC11, MAP6D1, ATG4C, PIGM, ZDHHC20 | 84 | 10 | 3.38 | 0.00152 | Down |
Regulation of axon guidance | BMPR2, NRP1, SEMA3A, TBR1, FEZF2 | 18 | 5 | 5.68 | 0.00441 | Up |
Regulation of neuron apoptotic process | CACNA1A, EPHA7, PTK2B, GABRA5, GABRB2, GABRB3, GRIK5, KCNB1, MEF2C, PAK3, PARK2, PIK3CA, PRKCG, CCL2, SNCB, SNCA, STAR, STXBP1, NRP1, CDK5R1, CHL1, PPARGC1A, NSMF, OXR1, FBXW7, AGAP2 | 183 | 26 | 2.47 | 9.7e-05 | Up |
Regulation of neurotransmitter levels | DAGLA, CACNA1A, CACNA1B, CAMK2A, DRD1, GABRA2, GAD1, GLS, GRIK5, MEF2C, PAK1, PARK2, PDE1B, PFN2, SLC1A1, SLC1A2, SNCA, STX1A, STXBP1, SYN1, SYN2, SYT1, SYT5, DOC2A, PPFIA4, PPFIA2, PPFIA3, CADPS, LIN7A, SYNJ1, SYT7, DGKI, BZRAP1, NRXN1, RIMS2, RIMS3, CPLX1, HRH3, ADGRL1, RAB3GAP1, RIMS1, UNC13A, PCLO, SYTL2, SLC17A7, SYT13, SYT16, SYT12, CADPS2, SNAP47 | 192 | 50 | 5.4 | 3.37e-18 | Up |
Regulation of postsynaptic membrane potential | DLG4, PTK2B, FGF14, GABRB3, GRIK5, GRIN2A, GRIN2B, MEF2C, PPP3CA, SNCA, STX1A, DGKI, NRXN1, RIMS2, RAB3GAP1, RIMS1, MAPK8IP2, SHANK1, CELF4, SLC17A7, NETO1, SHANK3 | 59 | 22 | 8.92 | 3.58e-12 | Up |
Regulation of synaptic plasticity | ATP2B2, CAMK2A, CAMK2B, DLG4, DRD1, PTK2B, FGF14, GRIA1, GRIN2A, GRIN2B, GRM5, HRH2, ITPKA, KCNB1, MEF2C, NEUROD2, NRGN, PAK1, PPP3CB, PTGS2, PTN, SNCA, STAR, STXBP1, NR2E1, PPFIA3, SYNGAP1, SYNGR1, NEURL1, DGKI, RAPGEF2, BAIAP2, PLK2, CPEB3, RAB3GAP1, RIMS1, UNC13A, NSMF, NPTN, JPH3, NETO1, JPH4, SHANK3, SNAP47, CNTN4, LRRTM1 | 132 | 46 | 8.2 | 1.48e-22 | Up |
Regulatory region nucleic acid binding | ARNTL, ETV1, H2AFZ, HIVEP2, MEF2C, NEUROD2, PLAGL1, RARA, SATB1, SNCA, SOX5, STAT4, TBX15, LMO4, ZBTB33, BASP1, TBR1, KLF12, DDN, BCL11A, FEZF2, ARNTL2, PKNOX2, DMRTC1, NEUROD6, BCL11B, ZNF831, ZNF519, ARX, ZNF675, STOX1, SOHLH1, DMRTC1B | 790 | 33 | 0.643 | 0.00634 | Down |
Release of cytochrome c from mitochondria | CCK, IFI6, HGF, IGF1, PARK2, MAPK9, HRK, DNM1L, MLLT11, GGCT | 55 | 10 | 3.29 | 0.00222 | Up |
SNARE binding | CACNA1A, STX1A, STXBP1, SYT1, SYT5, DOC2A, NAPG, SYT7, STXBP5L, CPLX1, UNC13A, SYTL2, SYT13, NAPB, SYT16, SYT12, SNAP47, STXBP5 | 112 | 18 | 2.91 | 0.000188 | Up |
Sodium channel activity | SHROOM2, SCN1A, SCN1B, SCN2A, SCN2B, SCN8A, SCN3B, HCN1 | 36 | 8 | 4.32 | 0.00141 | Up |
Synapse | ADD2, ATP1A1, ATP2B1, ATP2B2, BMPR2, CACNA1C, CACNB4, CAMK2A, CAMK2B, CAMK2D, CCK, CHRM1, CHRM3, AP1S1, CTNNA2, DLG3, DLG4, DRD1, DMTN, EPHA4, EPHA7, PTK2B, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRB2, GABRB3, GABRD, GABRG3, GAP43, GLRB, GRIA1, GRIA2, GRIA3, GRIK5, GRIN2A, GRIN2B, GRM1, GRM5, GRM8, ICA1, ITPKA, ITPR1, KCNB1, KCNC2, KCNH1, KCNJ4, KCNMA1, MAP2, MYH10, NPY1R, NRCAM, NRGN, OPRK1, PAK1, PDE2A, PFN2, PRKAR2B, PRKCG, PTPRN2, CCL2, SLC8A1, SNCB, SNCA, STX1A, STXBP1, SYN1, SYN2, SYT1, SYT5, SLC30A3, FZD3, GLRA3, DOC2A, PRSS12, PPFIA4, PPFIA2, KCNAB2, ITGA8, PPFIA3, CADPS, LIN7A, CDK5R1, BSN, WASF1, SYT7, SYNGR1, NEURL1, DGKI, DLGAP2, DLGAP1, NRXN1, HOMER1, CABP1, AKAP5, GABBR2, RAPGEF2, RIMS2, ARHGAP32, FRMPD4, LZTS3, RIMS3, SV2B, DNM1L, OLFM1, BAIAP2, SLC9A6, CAP2, ARFGEF2, CPLX1, LZTS1, AAK1, CPEB3, ADGRL1, CNKSR2, CLSTN1, RIMS1, PDZRN3, UNC13A, NMNAT2, DDN, DMXL2, SYNE1, NCS1, MAPK8IP2, FRRS1L, MYRIP, NSMF, ERC2, CYFIP2, NPTN, PCLO, PACSIN1, SHANK1, NRN1, SVOP, SEPT11, SEPT3, ANKS1B, SLC17A7, TENM2, TBC1D24, LRFN2, KCTD16, LRRC7, DLGAP3, CACNG8, CLSTN2, LRRTM4, NETO1, PPP1R9B, SHANK3, SYT12, CADPS2, PRRT2, GRIN3A, OLFM3, TPRG1L, SYNPR, STXBP5, CBLN4, GRASP, SCAMP5, PHACTR1, CNIH2, LRRTM1, LRRTM3, VWC2, SLC6A17, IQSEC3, UNC13C | 658 | 173 | 6.11 | 1.15e-62 | Up |
Synapse maturation | CAMK2B, NEUROD2, NEURL1, NRXN1, ADGRL1, SHANK1 | 18 | 6 | 7.39 | 0.000626 | Up |
Synaptic transmission | ADCY1, ATP2B2, CA7, CACNA1A, CACNA1B, CACNA1C, CACNB1, CACNB2, CACNB4, CAMK4, CAMK2A, CAMK2B, CAMK2D, CHRM1, CHRM3, DLG3, DLG4, DRD1, EGR3, PTK2B, FGF14, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRB2, GABRB3, GABRD, GABRG3, GAD1, GLRB, GLS, GNAI3, GRIA1, GRIA2, GRIA3, GRIK5, GRIN2A, GRIN2B, GRM1, GRM5, GRM8, HRH2, HTR1B, HTR1E, HTR1F, HTR2A, ITPKA, KCNB1, KCNC1, KCNC2, KCND3, KCNF1, KCNH1, KCNJ3, KCNJ4, KCNJ6, KCNJ9, KCNK2, KCNMA1, KCNN1, KCNQ2, KCNQ3, KCNS1, KCNS2, KIF5A, MEF2C, MYO5A, NEUROD2, NPY5R, OPRK1, OPRM1, PAK1, PARK2, PFN2, PPP3CA, PPP3CB, PRKCB, PRKCE, PRKCG, PTGS2, PTN, RIT2, SCN1B, SCN2B, CCL2, SLC1A1, SLC1A2, SNCB, SNCA, SSTR2, SSTR4, STAR, STX1A, STXBP1, SYN1, SYN2, SYT1, SYT5, NR2E1, VIPR1, KCNAB1, GLRA3, DOC2A, PPFIA4, PPFIA2, KCNAB2, PPFIA3, CADPS, LIN7A, SYNGAP1, SYNJ1, BSN, SYT7, SYNGR1, NEURL1, DGKI, KCNAB3, DLGAP2, DLGAP1, BZRAP1, NRXN1, HOMER1, AKAP5, GABBR2, RAPGEF2, RIMS2, RIMS3, SNAP91, CACNG3, BAIAP2, CSPG5, PLK2, CPLX1, HRH3, CPEB3, ADGRL1, CLSTN1, RAB3GAP1, RIMS1, UNC13A, PLCB1, KCNH4, KCNH3, MAPK8IP2, RASD2, NSMF, SLITRK5, KCNV1, NPTN, KCNH5, PCLO, TMOD2, KCNIP2, SHANK1, SHC3, SYTL2, PCDHB13, KCNQ5, CELF4, SLC17A7, JPH3, SYT13, CACNG8, CLSTN2, NETO1, SYT16, CAMKK1, JPH4, PPP1R9B, SHANK3, KCNH7, SYT12, CADPS2, BTBD9, GRIN3A, SNAP47, CNTN4, KCNG3, CNIH2, LRRTM1, HCN1, UNC13C | 702 | 184 | 6.18 | 1.54e-66 | Up |
Synaptic transmission, glutamatergic | CACNA1A, CACNB4, DRD1, PTK2B, GRIA1, GRIA2, GRIA3, GRIK5, GRIN2A, GRM1, GRM5, GRM8, HTR1B, HTR2A, MEF2C, PAK1, PARK2, PTGS2, SYT1, DGKI, NRXN1, RAB3GAP1, UNC13A, MAPK8IP2, SHC3, SLC17A7, SHANK3, GRIN3A, CNIH2 | 78 | 29 | 8.94 | 1.42e-15 | Up |
Synaptic vesicle exocytosis | GRIK5, PFN2, STX1A, STXBP1, SYN1, SYT1, SYT5, DOC2A, CADPS, SYNJ1, SYT7, RIMS3, CPLX1, ADGRL1, RIMS1, UNC13A, PCLO, SYTL2, SYT13, SYT16, SYT12, CADPS2, SNAP47 | 76 | 23 | 6.51 | 1.59e-10 | Up |
Synaptic vesicle localization | FGF14, GRIK5, PARK2, PFN2, SH3GL2, SNCA, STX1A, STXBP1, SYN1, SYT1, SYT5, AP3B2, DOC2A, CADPS, LIN7A, SYNJ1, SYT7, NRXN1, RIMS3, CPLX1, ADGRL1, RIMS1, UNC13A, PCLO, PACSIN1, SYTL2, SYT13, SYT16, SYT12, CADPS2, BTBD9, SNAP47 | 120 | 32 | 5.49 | 1.97e-12 | Up |
Synaptic vesicle membrane | ICA1, STX1A, SYN1, SYN2, SYT1, SYT5, SLC30A3, DOC2A, SYT7, SYNGR1, SV2B, DNM1L, DMXL2, SVOP, SLC17A7, SYT12, SYNPR, SCAMP5, SLC6A17 | 55 | 19 | 7.94 | 4.52e-10 | Up |
Synaptic vesicle priming | STX1A, STXBP1, CADPS, SYNJ1, CADPS2, SNAP47 | 12 | 6 | 14.8 | 4.34e-05 | Up |
Synaptic vesicle recycling | FGF14, SH3GL2, SNCA, SYT1, SYT5, SYNJ1, PACSIN1, BTBD9 | 29 | 8 | 5.64 | 0.000338 | Up |
Synaptic vesicle transport | FGF14, GRIK5, PARK2, PFN2, SH3GL2, SNCA, STX1A, STXBP1, SYN1, SYT1, SYT5, AP3B2, DOC2A, CADPS, LIN7A, SYNJ1, SYT7, RIMS3, CPLX1, ADGRL1, RIMS1, UNC13A, PCLO, PACSIN1, SYTL2, SYT13, SYT16, SYT12, CADPS2, BTBD9, SNAP47 | 116 | 31 | 5.51 | 4.11e-12 | Up |
Syntaxin binding | CACNA1A, STXBP1, SYT1, SYT5, DOC2A, NAPG, SYT7, STXBP5L, CPLX1, UNC13A, SYTL2, SYT13, NAPB, SYT16, SYT12, SNAP47, STXBP5 | 78 | 17 | 4.24 | 4.82e-06 | Up |
Terminal bouton | CCK, AP1S1, GRIK5, GRIN2A, KCNC2, KCNMA1, PFN2, PTPRN2, SNCA, STXBP1, SYN1, PRSS12, SYT7, SYNGR1, CPLX1, AAK1, TBC1D24 | 61 | 17 | 5.8 | 1.39e-07 | Up |