Research Paper Volume 9, Issue 12 pp 2480—2488
Transfer of autologous mitochondria from adipose tissue-derived stem cells rescues oocyte quality and infertility in aged mice
- 1 State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
- 2 University of Chinese Academy of Sciences, Beijing 100101, China
- 3 Department of Obstetrics and Gynecology, General Hospital of Chinese People’s Liberation Army, Beijing 100853, China
- 4 Center for Reproductive Medicine, Guangdong Second Provincial General Hospital, Guangzhou 510317, China
- 5 The Core Facilities at School of Life Sciences, Peking University, Beijing 100871, China
received: August 10, 2017 ; accepted: November 26, 2017 ; published: December 27, 2017 ;https://doi.org/10.18632/aging.101332
How to Cite
Copyright: Wang et al. This is an open‐access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Elder women suffer from low or loss of fertility because of decreasing oocyte quality as maternal aging. As energy resource, mitochondria play pivotal roles in oocyte development, determining oocyte quality. With advanced maternal age, increased dysfunctions emerge in oocyte mitochondria, which decrease oocyte quality and its developmental potential. Mitochondria supplement as a possible strategy for improving egg quality has been in debate due to ethnic problems. Heterogeneity is an intractable problem even transfer of germinal vesicle, spindle, pronuclei or polar body is employed. We proposed that the autologous adipose tissue-derived stem cell (ADSC) mitochondria could improve the fertility in aged mice. We found that autologous ADSC mitochondria could promote oocyte quality, embryo development and fertility in aged mice, which may provide a promising strategy for treatment of low fertility or infertility in elder women.