Research Paper Volume 10, Issue 6 pp 1402—1414

The role of microRNA-608 polymorphism on the susceptibility and survival of cancer: a meta-analysis

Zhi-Ming Dai 1, *, , Jian-Rui Lv 1, *, , Kang Liu 2, *, , Xiao-Ming Lei 1, , Wei Li 1, , Gang Wu 1, , Xing-Han Liu 2, , Yu-Xiao Zhu 2, , Qian Hao 2, , Zhi-Jun Dai 2, ,

  • 1 Department of Anesthesiology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710004, China
  • 2 Department of Oncology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710004, China
* Equal contribution

received: January 17, 2018 ; accepted: June 10, 2018 ; published: June 16, 2018 ;
How to Cite

Copyright: Dai et al. This is an open‐access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The role of rs4919510 polymorphism in microRNA-608 (miR-608) and cancer susceptibility and prognosis remain controversial and debatable. We conducted a meta-analysis of twenty-four eligible publications on the association of rs4919510 polymorphism with cancer risk and/or prognosis. Odds ratios, hazard ratios, and 95% confidence interval were used to investigate the association between this polymorphism and susceptibility, overall survival, and recurrence-free survival of cancer. Overall, eighteen case-control studies and nine cohort studies evaluated the susceptibility and prognostic value of rs4919510 polymorphism in cancer, respectively. Pooled analysis showed that rs4919510 polymorphism was not associated with cancer risk in all five genetic models. When stratifying by different cancer sites, rs4919510 polymorphism was detected to have a significant association with a decreased risk of colorectal cancer in homozygous model (P = 0.006) and recessive model (P = 0.001), subgroup analysis also emerged a weakened correlation between rs4919510 polymorphism and an increased risk of papillary thyroid cancer in heterozygote model (P = 0.04). Furthermore, the prognosis of rs4919510 variant in cancer patients showed that rs4919510 GG genotype was significant association with poor recurrence-free survival in homozygous models (P = 0.04). The meta-analysis suggested that the microRNA-608 rs4919510 polymorphism maybe associate with a significantly decreased risk for colorectal cancer. Further investigations on larger populations are required to evaluate and confirm this relationship.


OR: odds ratio; HR: hazard ratio, CI: confidence interva; RFS: recurrence-free surviva; HWE: Hardy-Weinberg equilibriu; PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-analyse; CNKI: Chinese National Knowledge Infrastructur; MeSH: medical subject headin; NOS: Newcastle-Ottawa Scale.