Research Paper Volume 10, Issue 10 pp 2900—2910
Can mesenchymal stem cell lysate reverse aging?
- 1 Laboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan
- 2 Université Catholique de Louvain and de Duve Institute, Brussels, Belgium
- 3 Stem Cell Research Center, National Yang-Ming University, Taipei, Taiwan
- 4 Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre and Department of Physiology and Pathophysiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
- 5 Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan
- 6 Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan
- 7 Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan
Received: August 21, 2018 Accepted: October 12, 2018 Published: October 24, 2018
https://doi.org/10.18632/aging.101595How to Cite
Abstract
Recent findings regarding uses of adipose-derived mesenchymal stem cell (MSC)-lysate on weight loss and improved glucose tolerance in mice on a high-fat diet suggest an encouraging possibility of using MSC lysate for an anti-aging intervention in humans. However, weight loss and lipopenia during late life can be as life-threatening as hyperglycemia during early adulthood. For this 3-year lifelong experiment, a total of 92 rats were randomized into the vehicle-injected group (F=22; M=24) and the MSC lysate injected group (F=22, M=24). We examined longevity, spontaneous locomotor activity, and body composition in rats maintained on a normal diet and received an intermittent treatment of human adipose-derived MSC lysate (3 times a week, 11 times a month given every second month), starting at 12 months of age until natural death. In substantiating previous knowledge regarding the effects of long-term MSC lysate treatments on fat loss and insulin resistance, the present findings also highlighted a shortened average lifespan, a longer inactive time, and a greater bone loss with a relative increase of lean mass in MSC lysate rats with respect to controls. Conclusion: Our data suggest that MSC lysate treatments stimulate disparity in tissue development and produce a cachexia-like effect to decrease longevity.