Review Volume 10, Issue 12 pp 4269—4288
Protein synthesis and quality control in aging
- 1 Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119234, Russia
- 2 School of Bioengineering and Bioinformatics Lomonosov Moscow State University, Moscow 119234, Russia
- 3 Bach Institute of Biochemistry of the Russian Academy of Sciences, Moscow 119071, Russia
- 4 Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA
- 5 Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia
received: October 18, 2018 ; accepted: December 10, 2018 ; published: December 18, 2018 ;https://doi.org/10.18632/aging.101721
How to Cite
Copyright: Anisimova et al. This is an open‐access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Aging is characterized by the accumulation of damage and other deleterious changes, leading to the loss of functionality and fitness. Age-related changes occur at most levels of organization of a living organism (molecular, organellar, cellular, tissue and organ). However, protein synthesis is a major biological process, and thus understanding how it changes with age is of paramount importance. Here, we discuss the relationships between lifespan, aging, protein synthesis and translational control, and expand this analysis to the various aspects of proteome behavior in organisms with age. Characterizing the consequences of changes in protein synthesis and translation fidelity, and determining whether altered translation is pathological or adaptive is necessary for understanding the aging process, as well as for developing approaches to target dysfunction in translation as a strategy for extending lifespan.