Research Paper Volume 11, Issue 11 pp 3551—3560
Age-related changes in the vasculature of the dermis of the upper lip vermilion
- 1 Cell Regulation Laboratory, Bionics Program, Tokyo University of Technology Graduate School of Bionics, Computer and Media Science, Hachioji, Japan
- 2 Frontier Research Center, POLA Chemical Industries Inc., Yokohama, Japan
received: March 1, 2018 ; accepted: May 23, 2019 ; published: June 6, 2019 ;https://doi.org/10.18632/aging.101996
How to Cite
Copyright: Gomi and Imamura. This is an open‐access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Lip redness is unique to humans and creates an important facial impression, but this redness decreases with age. Here, using histological and immunohistological staining of human upper lip vermilion from donors of different ages, we investigated blood vessels in the upper lip dermis and age-dependent histological changes. We found that both total vessel area in the dermis and vessel number in the upper dermis decreased with aging. Moreover, vessel number in the upper dermis correlated positively with development of rete ridges, which flattened with age, despite no significant change in the thickness of the stratified squamous epithelium. These findings suggest that age-related reductions in lip redness result from a decrease of blood vessels, which in turn leads to a flattening of the epithelium caused by the loss of rete ridges. This is the first study to histologically demonstrate age-related reductions in blood vessels in the lip. Our results provide an opportunity for enhancing blood flow/vascularization to improve the aesthetic appearance of the lips in the elderly.