Research Paper Volume 11, Issue 13 pp 4438—4445

Fasting blood glucose level and hypertension risk in aging benign prostatic hyperplasia patients

Hao Zi 1, 2, 3, , Xue-Jun Wang 4, , Ming-Juan Zhao 2, 3, 5, , Qiao Huang 2, , Xing-Huan Wang 1, 2, , Xian-Tao Zeng 1, 2, , on behalf of BPSC investigators,

  • 1 Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China
  • 2 Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China
  • 3 Center for Evidence-Based Medicine, Institute of Evidence-Based Medicine and Knowledge Translation, Henan University, Kaifeng, Henan 475000, China
  • 4 Department of Emergency, Beijing Electric Power Hospital, Beijing 100073, China
  • 5 Department of Cardiology, The First Affiliated Hospital of Henan University, Kaifeng, Henan 475000, China

received: March 9, 2019 ; accepted: June 24, 2019 ; published: July 3, 2019 ;

https://doi.org/10.18632/aging.102061
How to Cite

Copyright: Zi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Evidence suggests there maybe an association among abnormal fasting blood glucose, hypertension and benign prostatic hyperplasia. In this study, we investigated whether abnormal fasting blood glucose correlates with hypertension in aging benign prostatic hyperplasia patients. Ultimately, 612 benign prostatic hyperplasia patients, including 230 hypertensive patients and 382 normotensive patients, were included. Univariate and multivariate logistic regression analyses were used to evaluate the associations. The results indicated that neither impaired fasting glucose/high risk of type 2 diabetes mellitus nor high risk of type 2 diabetes mellitus were associated with an increased risk of hypertension. When patients were stratified based on the severity of their hypertension, similar results were obtained (all P> 0.05). After adjusting for confounding factors, the nonsignificant tendencies for high risk of type 2 diabetes mellitus and impaired fasting glucose/high risk of type 2 diabetes mellitus to associate with hypertension persisted (all P> 0.05). Unlike earlier studies, the present study suggests that the level of fasting blood glucose may not be significantly related to hypertension in aging patients with benign prostatic hyperplasia.

Abbreviations

BMI: body mass index; BPH: benign prostatic hyperplasia; BPSC: the Bladder Cancer and Benign Prostatic Hyperplasia Study in Chinese Population; DBP: diastolic blood pressure; FBG: fasting blood glucose; HDL-C: high-density lipoprotein cholesterol; HR-T2DM: high risk of type 2 diabetes mellitus; IFG: impaired fasting glucose; IPSS: international prostate symptom score; OR: odds ratio; STROBE: STrengthening the Reporting of OBservational studies in Epidemiology; SD: standard deviation; SBP: systolic blood pressure; T2DM: type 2 diabetes mellitus; t-PSA: total prostate specific antigen; VEGF: vascular endothelial growth factor.